Male Mutation Bias in Insertions and Deletions That Accumulated in the Ancestral Repeats in Rat and Mouse Since Their Divergence From the Common Ancestor
|
Indel type |
NX |
RateX |
NA |
RateA |
X/A |
α (95% CI) |
|---|---|---|---|---|---|---|
| Mouse deletions | 22,278 | 0.0041 | 468,707 | 0.0047 | 0.871 | 2.260 (1.961—2.630) |
| Rat deletions | 24,924 | 0.0046 | 542,992 | 0.0054 | 0.841 | 2.818 (2.440—3.291) |
| Total deletions | 47,202 | 0.0086 | 1,011,699 | 0.0101 | 0.855 | 2.538 (2.200—2.957) |
| Mouse insertions | 12,375 | 0.0023 | 251,339 | 0.0025 | 0.902 | 1.828 (1.561—2.157) |
| Rat insertions | 11,001 | 0.0020 | 226,459 | 0.0023 | 0.890 | 1.980 (1.679—2.361) |
| Total insertions | 23,376 | 0.0043 | 477,798 | 0.0048 | 0.897 | 1.898 (1.616—2.251) |
| Indels
|
70,578
|
0.0129
|
1,489,497
|
0.0148
|
0.869
|
2.304 (1.986—2.699)
|
-
All ARs (“younger” and “older”) are considered together. NX and NA indicate the numbers of indels that accumulated on chromosome X and autosomes, respectively; rateX and rateA, the indel rates (a number of indels per base pair of alignment) on chromosome X and autosomes, respectively; X/A, the ratio of indel rates on chromosome X versus autosomes; and α (95% CI), the male-to female mutation rate ratio and its 95% confidence interval: 5,477,266 bp and 100,388,643 bp in the ancestral repeats were analyzed on chromosome X and autosomes, respectively.
