Occurrence and Consequences of Coding Sequence Insertions and Deletions in Mammalian Genomes

Table 4.

Frequency of CpG Dinucleotides in the Proximity of Indel Events

	10-bp window					50-bp window
	Observed (CpG %)	Simulated (CpG %)	p^a	Observed CpG %)	Simulated (CpG %)	p^a
Slippage-like	2.54	2.90	ns	3.25	2.83	<0.001
Non-slippage-like	3.53	2.90	<0.01	3.28	2.83	<0.001
Insertion	5.30	2.87	<0.0001	3.90	2.83	<0.0001
Deletion	2.70	2.93	ns	2.71	2.83	ns
Slippage-like insertion	5.48	2.90	<0.0001	3.62	2.83	<0.0001
Slippage-like deletion	2.54	2.90	ns	2.75	2.83	ns
Non-slippage-like insertion	5.17	2.90	<0.0001	4.44	2.83	<0.0001
Non-slippage-like deletion	3.02	2.90	ns	2.91	2.83	ns

↵a Significance calculated as a non-paired, two-tailed t-test between the distribution of CpG dinucleotide frequencies in observed and simulated data sets. Nonsignificant values (p > 0.01) are denoted by ns

This Article

Genome Res. 2004. 14: 555-566

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