Eukaryotic Regulatory Element Conservation Analysis and Identification Using Comparative Genomics

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Figure 1
Figure 1

Conservation of known human regulatory elements between human and mouse. (A) Histogram of percent identity values of known human regulatory elements between human and mouse. (B) Histogram of WPID values (21-bp window) of known human regulatory elements (dark) and background sequences (light) within 1000 bp upstream of TSS. In general, the 21-bp windows around known human regulatory elements are more conserved between human and mouse than those around background sequences. (C) Cumulative distribution of WPID values of known human regulatory elements and background sequences. WPID value cutoffs around 0.5 to 0.8 seem to give the biggest fraction difference between regulatory elements and background.

This Article

  1. Genome Res. 14: 451-458

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