Parallel Genotyping of Over 10,000 SNPs Using a One-Primer Assay on a High-Density Oligonucleotide Array

Table 3A.

Call Rates and Heterozygosities in Thirteen Ethnic Groups




Individuals

Mean call rate

Median heterozygosity

Mean heterozygosity

Nonpolymorphic
African-American 42 96.5% ± 1.2% 0.39 0.35 ± 0.14 109
Caucasian 42 98.5% ± 0.6% 0.40 0.35 ± 0.15 402
Mende 22 95.0% ± 1.6% 0.35 0.31 ± 0.16 868
South Asian 22 96.6% ± 0.9% 0.39 0.35 ± 0.15 555
Mbuti Pygmy 20 96.3% ± 1.3% 0.29 0.27 ± 0.17 1518
East Asian 20 97.3% ± 1.2% 0.38 0.32 ± 0.17 1168
Nahua 20 93.1% ± 1.5% 0.32 0.28 ± 0.18 1865
Puerto Rican 20 92.7% ± 3.0% 0.40 0.35 ± 0.14 362
Quechua 20 95.1% ± 0.9% 0.32 0.29 ± 0.18 1566
Altaian 20 97.5% ± 2.1% 0.39 0.34 ± 0.15 601
Spanish 20 93.8% ± 2.3% 0.38 0.33 ± 0.16 710
Burunge 20 92.9% ± 4.8% 0.38 0.33 ± 0.15 599
Nasioi 19 97.1% ± 1.8% 0.30 0.27 ± 0.18 2145
*Across all groups
307
95.9% ± 2.6%
0.41
0.38 ± 0.12
4
  • Standard deviations of call rates represent the variance among individuals within the groups, and standard deviations of the heterozygosity values represent the variance among the 11,555 SNPs. Values are calculated for each ethnic group and *for the entire set of 307 individuals aggregated as one common group. Heterozygosity is calculated as 2pq, where p = frequency of allele A and q = frequency of allele B.

This Article

  1. Genome Res. 14: 414-425

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