(A) Distribution of SNPs across the genome. Physical map assignments of 11,384 SNPs are based on the November 2002 release of the UCSC Golden Path (http://genome.ucsc.edu/). Red vertical bars represent the presence of at least one SNP in 100-kb regions. Black vertical bars represent large contig gaps that are 100,000 N's or longer. The Y chromosome is not shown because none of the 11,555 SNPs map to this chromosome. (B) SNPs distributed on the basis of genetic distances across the genome. Red bars represent the presence of at least one genotyped SNP in 0.1-cM intervals. Genetic distance assignments were based on interpolations against the deCODE STR genetic map (Kong et al. 2002). STR markers that had discrepant chromosome assignments and ordering between the deCODE map and Golden Path were omitted from the interpolation. Pairs of deCODE STRs with unique physical positions were used as local landmarks to interpolate genetic distances for SNPs located between the STRs. The interpolation makes the simplifying assumption that physical and genetic distances correlate linearly over the short localized regions of the chromosomes defined by pairs of STRs drawn from the 5136 STRs on the deCODE map. Physical map positions as well as the interpolated genetic distances are reported for each SNP in the Supplemental material (SNP Information).
