Patterns of misregulation between hybrids and females of D. melanogaster and D. simulans in whole-body experiments. (A) orb, a gene underexpressed in the hybrid and required for correct oogenesis in a normal female. (B) Adh, a gene overexpressed in the hybrid that is highly expressed in the fat body (Dickinson et al. 1984). (C) dream, a gene for which the allele of D. melanogaster is dominant over that of D. simulans, which involves a higher level of expression. (D) sxe2, a gene overexpressed in the hybrid that is expressed in the brain of males only (Fujii and Amrein 2002). Female symbol subscripts indicate the genotype; (m) D. melanogaster; (s) D. simulans; (h) hybrid. Error bars indicate the 95% credible intervals around the estimated mean expression level. Three pairwise comparisons are possible among the three female genotypes. Differences in level of gene expression are regarded to be statistically significant if the 95% credible intervals of the estimates failed to overlap. (=) No significant difference; (>) significant overexpression.
