Gene Conversion and the Evolution of Protocadherin Gene Cluster Diversity

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Figure 5
Figure 5

Sequence homogenization in protocadherin cluster genes is lineage-specific. The gene tree of human, mouse, and rat Pcdhα (A) and Pcdhβ (C) EC3 domains recapitulates the orthologous relationships among the full-length genes. These relationships break down in Pcdhα EC5 (B) and Pcdhβ EC6 (D) domains, where paralogs within each species are more similar to each other than they are to their orthologs in related species.

This Article

  1. Genome Res. 14: 354-366

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