Gene Conversion and the Evolution of Protocadherin Gene Cluster Diversity

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Figure 4
Figure 4

Ectodomain-specific sequence homogenization in protocadherin cluster genes. The human Pcdhβ ectodomain (EC) 3 gene tree (A) reflects the sequence diversity among Pcdhβ paralogs. Pcdhβ ectodomain 6, however, is almost completely homogenized (B), with otherwise diverse Pcdhβ genes (e.g., β3 and β9) having identical EC6 sequences. This phenomenon is pronounced in zebrafish, where DrPcdh1γ genes with very divergent EC3 domains (C) have nearly identical EC6 domains (D).

This Article

  1. Genome Res. 14: 354-366

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