Patterns of Evolutionary Constraints in Intronic and Intergenic DNA of Drosophila

Table 3.

Estimates of Constraint in Runs of Nucleotides Close to the 5′- or 3′-Ends of Introns, Calculated Using the Two Lineage Method, Applied to Sequences from D. melanogaster and D. simulans




Substitutions

Intron end
Base pairs
Observed (SEM)
Expected (SEM)
Constraint (SEM)
5′ 1–2 0 (0.0) 0.294 (0.021) 1.00 (0.00)
3–4 0.145 (0.037) 0.277 (0.021) 0.47 (0.13)
5–6 0.055 (0.024) 0.295 (0.022) 0.82 (0.077)
3′ 1–2 0 (0.0) 0.292 (0.021) 1.00 (0.00)

3–16
2.248 (0.202)
1.912 (0.142)
–0.178 (0.098)

This Article

  1. Genome Res. 14: 273-279

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