Table 1.
Methylation and Other Features of CpG Islands on Human Chromosome 21q
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Nucleotide positione |
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| CpG islandsa |
Methylation |
Repeatb |
Locus |
GC %c |
Obs/expd |
Size (bp) |
Start |
End |
Location in the linked genef |
CGI-linked genes |
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| #1 (NT_002836.4 740746-742525) | Complete methylation | — | 21q11.1 | 72.0 | 0.88 | 780 | 13998888 | 13999667 | CDS | Similarity to feminization 1 homolog a (C. elegans) | |
| #2 (NT_002836.4 798428-799837) | Complete methylation | — | 21q11.1 | 72.2 | 0.80 | 410 | 14056570 | 14056979 | CDS | Similarity to feminization 1 homolog a (C. elegans) | |
| #3 (NT_002836.4 1099894-1101335) | Complete methylation | — | 21q11.1 | 68.1 | 0.80 | 442 | 14358036 | 14358477 | 5′-UTR and CDS | Similarity to hypothetical protein DKFZp434A171; KIAA0565; ankyrin repeat-containing proteins | |
| #4 (NT_002836.4 2100365-2102278) | Unmethylation | — | 21q11.2 | 76.2 | 0.98 | 914 | 15358453 | 15359366 | 5′-UTR | Nuclear receptor interacting protein 1 (NRIP1) | |
| #5 (NT_002836.4 2765740-2767861) | Unmethylation | — | 21q11.2 | 74.7 | 0.88 | 1320 | 16023802 | 16025122 | 5′-UTR and CDS | Ubiquitin specific protease 25 (USP25) | |
| #6 (NT_002836.4 4548804-4550994) | Unmethylation | — | 21q21.1 | 71.1 | 0.83 | 1229 | 17806771 | 17807999 | 5′-UTR and CDS | Coxsackie virus and adenovirus receptor (CXADR) | |
| #7 (NT_002836.4 4648389-4650557) | Unmethylation | — | 21q21.1 | 73.4 | 0.96 | 1169 | 17906356 | 17907524 | 5′-UTR | BTG family member 3 (BTG3) | |
| #8 (NT_002836.4 4854926-4857042) | Unmethylation | — | 21q21.1 | 68.0 | 0.97 | 1117 | 18112871 | 18113987 | 5′-UTR and CDS | Chromosome 21 open reading frame 91 (C21 orf91), hypothetical protein LOC54149 (YG81) | |
| #9 (NT_002836.4 12511562-12513060) | Unmethylation | — | 21q21.2 | 70.3 | 0.88 | 499 | 25856202 | 25856700 | — | ||
| #10 (NT_002836.4 12684911-12686522) | Unmethylation | — | 21q21.2 | 71.7 | 0.79 | 612 | 26029550 | 26030161 | 5′-UTR | ATP synthase H+ transporting mitochondrial F0 complex subunit F6 | |
| #11 (NT_002836.4 13119202-13121651) | Unmethylation | — | 21q21.3 | 70.8 | 0.83 | 1450 | 26463778 | 26465227 | 5′-UTR and CDS | Amyloid beta precursor protein (APP) | |
| #12 (NT_002836.4 13793868-13795756) | Unmethylation | — | 21q21.3 | 67.2 | 0.98 | 889 | 27138374 | 27139262 | 5′-UTR and CDS | Matrix metalloprotease (ADAMTS1) | |
| #13 (NT_002836.4 13915193-13916938) | Unmethylation | — | 21q21.3 | 70.1 | 0.87 | 746 | 27259699 | 27260444 | 5′-UTR and CDS | A disintegrin-like and metalloprotease with thrombospondin type 1 motif5 (ADAMTS5) | |
| #14 (NT_002836.4 13917154-13918663) | Unmethylation | — | 21q21.3 | 61.7 | 0.83 | 510 | 27261660 | 27262169 | — | ||
| #15 (NT_002836.4 15834745-15836237) | Unmethylation | — | 21q22.11 | 62.4 | 0.93 | 493 | 29179194 | 29179686 | 5′-UTR and CDS | Putative N6-DNA-methyltransferase (N6AMT1) | |
| #16 (NT_002836.4 16246692-16248676) | Unmethylation | — | 21q22.11 | 76.5 | 0.90 | 985 | 29591133 | 29592117 | 5′-UTR | BTB and CNC homology 1, basic leucine zipper transcription factor 1 (BACH1) | |
| #17 (NT_002836.4 18506100-18509038) | Incomplete methylation | — | 21q22.11 | 71.7 | 0.94 | 1939 | 31850340 | 31852278 | 5′-UTR | Similarity to T-lymphoma invasion and metastasis-inducing protein 1 (TIAM1) | |
| #18 (NT_002836.4 18607855-18609856) | Unmethylation | — | 21q22.11 | 69.0 | 0.94 | 1002 | 31952095 | 31953096 | 5′-UTR and CDS | Superoxide dismutase (SOD-1) | |
| #19 (NT_002836.4 18679791-18682057) | Unmethylation | — | 21q22.11 | 74.3 | 0.90 | 1267 | 32024044 | 32025310 | Similarity to CTD-binding SR-like protein rA4 | ||
| #20 (NT_002836.4 18821198-18823391) | Unmethylation | — | 21q22.11 | 72.7 | 0.87 | 1374 | 32165461 | 32166834 | 5′-UTR and CDS | Hormonally up-regulated Neu-associated kinase (HUNK) | |
| #21 (NT_002836.4 19227134-19228707) | Unmethylation | — | 21q22.11 | 65.1 | 0.85 | 574 | 32571397 | 32571970 | 5′-UTR and CDS | FAPP1-associated protein 1 (FASP1); chromosome 21 open reading frame 45 (C21orf45) | |
| #22 (NT_002836.4 19248734-19250388) | Complete methylation | + | 21q22.11 | 54.0 | 1.21 | 655 | 32592997 | 32593651 | — | ||
| #23 (NT_002836.4 19359982-19362161) | Unmethylation | — | 21q22.11 | 70.2 | 0.86 | 1180 | 32704245 | 32705424 | — | ||
| #24 (NT_002836.4 19561116-19562518) | Unmethylation | — | 21q22.11 | 62.0 | 0.82 | 403 | 32905379 | 32905781 | 5′-UTR | Chromosome 21 open reading frame 59 (C21orf59) | |
| #25 (NT_002836.4 19675812-19677620) | Unmethylation | — | 21q22.11 | 71.4 | 0.83 | 809 | 33020075 | 33020883 | 5′-UTR and CDS | Synaptojanin 1 (SYNJ1) | |
| #26 (NT_002836.4 19719511-19721351) | Unmethylation | — | 21q22.11 | 70.2 | 0.98 | 841 | 33063774 | 33064614 | 5′-UTR and CDS | Chromosome 21 open reading frame 66 (C21orf66); Putative transcription factor (ORF1) | |
| #27 (NT_002836.4 19972011-19973417) | Unmethylation | — | 21q22.11 | 62.9 | 0.83 | 407 | 33316261 | 33316667 | — | ||
| #28 (NT_002836.4 19975198-19977216) | Unmethylation | — | 21q22.11 | 68.6 | 0.90 | 1019 | 33319448 | 33320466 | 5′-UTR, CDS and 3′-UTR | Oligodendrocyte lineage transcription factor 2 (OLIG2) | |
| #29 (NT_002836.4 20018303-20020533) | Unmethylation | — | 21q22.11 | 73.9 | 0.84 | 1283 | 33362553 | 33363835 | 5′-UTR, CDS and 3′-UTR | Oligodendrocyte transcription factor 1 (Olig1) | |
| #30 (NT_002836.4 20178164-20179883) | Unmethylation | — | 21q22.11 | 72.0 | 0.99 | 720 | 33522413 | 33523132 | 5′-UTR | Interferon (alpha, beta and omega) receptor 2(IFNAR2) | |
| #31 (NT_002836.4 20273122-20274794) | Unmethylation | — | 21q22.11 | 64.7 | 0.93 | 673 | 33617371 | 33618043 | 5′-UTR and CDS | Interferon (alpha, beta and omega) receptor 1(IFNAR1) | |
| #32 (NT_002836.4 20351550-20353202) | Unmethylation | — | 21q22.11 | 79.1 | 0.87 | 653 | 33695798 | 33696450 | 5′-UTR and CDS | Interferon gamma receptor 2 (interferon gamma transducer 1) (IFNGR2) | |
| #33 (NT_002836.4 20427755-20429718) | Unmethylation | — | 21q22.11 | 73.0 | 0.93 | 964 | 33772003 | 33772966 | 5′-UTR | Chromosome 21 open reading frame 4 (C21orf4) | |
| #34 (NT_002836.4 20536702-20538471) | Unmethylation | — | 21q22.11 | 72.7 | 0.92 | 770 | 33880950 | 33881719 | 5′-UTR and CDS; 3′-UTR | Downstream neighbor of SON (DONSON); Crystallin, zeta (quinone reductase)-like 1 (CRYZL1) | |
| #35 (NT_002836.4 20590829-20592722) | Unmethylation | — | 21q22.12 | 75.8 | 0.88 | 894 | 33935077 | 33935970 | 5′-UTR | Intersectin 1 (SH3 domain protein) (ITSN1) | |
| #36 (NT_002836.4 21021661-21023784) | Unmethylation | — | 21q22.12 | 77.3 | 1.02 | 1124 | 34365908 | 34367031 | 5′-UTR and CDS | Mitochondrial ribosomal protein S6 (MRPS6) | |
| #37 (NT_002836.4 21323771-21325344) | Unmethylation | — | 21q22.12 | 68.1 | 0.84 | 574 | 34668018 | 34668591 | — | ||
| #38 (NT_002836.4 21562903-21564940) | Unmethylation | — | 21q22.12 | 75.3 | 0.95 | 1038 | 34907150 | 34908187 | 5′-UTR and CDS | Down syndrome critical region gene 1 (DSCR1) | |
| #39 (NT_002836.4 21617860-21620045) | Unmethylation | + | 21q22.12 | 75.8 | 0.88 | 1186 | 34962107 | 34963292 | — | ||
| #40 (NT_002836.4 21740221-21742136) | Complete methylation | — | 21q22.12 | 71.8 | 0.84 | 1064 | 35084468 | 35085531 | CDS and 3′-UTR | Runt-related transcription factor 1 (RUNX1); acute myeloid leukemia 1 (AML1) | |
| #41 (NT_002836.4 21835266-21836717) | Unmethylation | — | 21q22.12 | 67.2 | 0.79 | 452 | 35179513 | 35179964 | 5′-UTR and CDS | Runt-related transcription factor 1 (RUNX1); acute myeloid leukemia 1 (AML1) | |
| #42 (NT_002836.4 21837000-21839961) | Incomplete methylation | — | 21q22.12 | 73.9 | 0.90 | 1961 | 35181247 | 35183208 | 5′-UTR | Runt-related transcription factor 1 (RUNX1); acute myeloid leukemia 1 (AML1) | |
| #43 (NT_002836.4 22835347-22836774) | Complete methylation | — | 21q22.13 | 60.5 | 0.94 | 428 | 36179519 | 36179946 | 5′-UTR and CDS | Homo sapiens protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 2 (PPP1R2P2) | |
| #44 (NT_002836.4 23008324-23010418) | Unmethylation | — | 21q22.13 | 62.5 | 0.86 | 1095 | 36352469 | 36353563 | 5′-UTR | Chromosome 21 open reading frame 18 (C21orf18) | |
| #45 (NT_002836.4 23018419-23020042) | Unmethylation | — | 21q22.13 | 70.0 | 0.87 | 624 | 36362564 | 36363187 | 5′-UTR and CDS | Carbonyl reductase 1 (CBR1) | |
| $46 (NT_002836.4 23083543-23085110) | Unmethylation | — | 21q22.13 | 69.8 | 0.83 | 568 | 36427688 | 36428255 | 5′-UTR and CDS | Carbonyl reductase 3 (CBR3) | |
| #47 (NT_002836.4 23104500-23106945) | Unmethylation | — | 21q22.13 | 73.0 | 0.78 | 1446 | 36448645 | 36450090 | 5′-UTR | mRNA expressed in placenta | |
| #48 (NT_002836.4 23268373-23270063) | Unmethylation | — | 21q22.13 | 73.6 | 0.86 | 691 | 36612817 | 36613507 | 5′-UTR and CDS | Nuclear matrix protein NXP-2 (NXP-2) | |
| #49 (NT_002836.4 23333456-23335039) | Unmethylation | — | 21q22.13 | 76.8 | 0.79 | 584 | 36677900 | 36678483 | 5′-UTR and CDS | Similarity to chromatin assembly factor 1 subunit B (p60) | |
| #50 (NT_002836.4 23646833-23649367) | Unmethylation | — | 21q22.13 | 74.0 | 0.83 | 1535 | 36991300 | 36992834 | 5′-UTR and CDS | Single-minded (Drosophila) homolog 2 (SIM2) transcript variant SIM2s | |
| #51 (NT_002836.4 23648887-23650365) | Unmethylation | — | 21q22.13 | 65.9 | 0.75 | 479 | 36993354 | 36993832 | Intron | Single-minded (Drosophila) homolog 2 (SIM2) | |
| #52 (NT_002836.4 23657131-23658548) | Unmethylation | — | 21q22.13 | 71.7 | 0.80 | 418 | 37001598 | 37002015 | CDS | Single-minded (Drosophila) homolog 2 (SIM2) transcript variant SIM2s | |
| #53 (NT_002836.4 23695691-23697656) | Unmethylation | — | 21q22.13 | 73.8 | 0.99 | 966 | 37040158 | 37041123 | CDS and 3′-UTR | Single-minded (Drosophila) homolog 2 (SIM2) | |
| #54 (NT_002836.4 23914335-23916288) | Unmethylation | — | 21q22.13 | 78.5 | 0.82 | 954 | 37258805 | 37259758 | — | ||
| #55 (NT_002836.4 23928709-23930164) | Composite methylation | — | 21q22.13 | 69.3 | 0.75 | 456 | 37273178 | 37273633 | 5′-UTR | Holocarboxylase synthetase | |
| #56 (NT_002836.4 23938177-23939758) | Unmethylation | — | 21q22.13 | 74.2 | 0.85 | 582 | 37282645 | 37283226 | 5′-UTR | Holocarboxylase synthetase | |
| #57 (NT_002836.4 23953977-23956357) | Incomplete methylation | — | 21q22.13 | 70.2 | 0.82 | 1381 | 37298442 | 37299822 | 5′-UTR and CDS | Down syndrome critical region gene 6 (DSCR6) | |
| #58 (NT_002836.4 24021123-24022718) | Unmethylation | — | 21q22.13 | 73.6 | 0.90 | 596 | 37365583 | 37366178 | 5′-UTR | Down syndrome critical region gene 5 (DSCR5) | |
| #59 (NT_002836.4 24206418-24207868) | Composite methylation | — | 21q22.13 | 58.3 | 0.90 | 451 | 37550792 | 37551242 | Intron | Down syndrome critical region gene 3 (DSCR3) | |
| #60 (NT_002836.4 24215237-24217598) | Unmethylation | — | 21q22.13 | 67.5 | 0.78 | 1362 | 37559611 | 37560972 | 5′-UTR and CDS | Down syndrome critical region gene 3 (DSCR3) | |
| #61 (NT_002836.4 24314183-24317285) | Unmethylation | — | 21q22.13 | 75.0 | 0.95 | 2103 | 37658554 | 37660656 | 5′-UTR | Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (DYRK1A) | |
| #62 (NT_002836.4 24511883-24513479) | Unmethylation | — | 21q22.13 | 67.0 | 0.94 | 597 | 37856254 | 37856850 | — | ||
| #63 (NT_002836.4 25608278-25609973) | Unmethylation | — | 21q22.2 | 74.5 | 1.04 | 696 | 38952732 | 38953427 | 5′-UTR | Transcriptional regulator ERG2 gene | |
| #64 (NT_002836.4 25753617-25755681) | Unmethylation | — | 21q22.2 | 71.1 | 0.78 | 1259 | 39098071 | 39099329 | 5′-UTR | Erythroblastosis virus oncogene homolog 2 (ets-2) | |
| #65 (NT_002836.4 26130818-26133115) | Unmethylation | — | 21q22.2 | 66.7 | 0.86 | 1298 | 39475251 | 39476548 | 5′-UTR and CDS | Down syndrome critical region gene 2 (DSCR2) | |
| #66 (NT_002836.4 26259167-26262261) | Unmethylation | — | 21q22.2 | 71.5 | 0.91 | 2095 | 39604704 | 39606798 | 5′-UTR and CDS | WD repeat domain 9 (WDR9) | |
| #67 (NT_002836.4 26295243-26297124) | Unmethylation | — | 21q22.2 | 76.7 | 0.90 | 882 | 39640780 | 39641661 | 5′-UTR and CDS | High-mobility group (nonhistone chromosomal) protein 14 (HMG14) | |
| #68 (NT_002836.4 26325240-26326648) | Incomplete methylation | — | 21q22.2 | 61.8 | 1.02 | 409 | 39672415 | 39672823 | 5′-UTR and CDS | Tryptophan rich basic protein (WRB) | |
| #69 (NT_002836.4 26390768-26392267) | Unmethylation | — | 21q22.2 | 67.8 | 0.91 | 500 | 39737943 | 39738442 | 5′-UTR | Chromosome 21 open reading frame 13 (C21 orf13) | |
| #70 (NT_002836.4 26556991-26558660) | Unmethylation | — | 21q22.2 | 68.9 | 0.95 | 670 | 39904918 | 39905587 | 5′-UTR | C21 orf88 protein form A (C21 orf88) | |
| #71 (NT_002836.4 27791317-27792866) | Unmethylation | — | 21q22.2 | 75.2 | 0.99 | 550 | 41138898 | 41139447 | 5′-UTR and CDS | Down syndrome cell adhesion molecule (DSCAM) | |
| #72 (NT_002836.4 28112154-28114765) | Unmethylation | — | 21q22.3 | 73.4 | 0.81 | 1612 | 41459726 | 41461337 | 5′-UTR and CDS | Beta-site APP-cleaving enzyme 2 (BACE2) | |
| #73 (NT_002836.4 28452242-28454382) | Unmethylation | — | 21q22.3 | 72.2 | 0.73 | 1141 | 41799550 | 41800690 | — | ||
| #74 (NT_001035.5 179474-181456) | Composite methylation | — | 21q22.3 | 70.9 | 0.87 | 983 | 42072090 | 42073072 | 5′-UTR and CDS | Ankyrin repeat domain 3 (ANKRD3) | |
| #75 (NT_003545.2 47617-49632) | Complete methylation | — | 21q22.3 | 78.3 | 1.00 | 1016 | 42192927 | 42193942 | CDS | PR-domain zinc finger protein 15 (PRDM15) | |
| #76 (NT_003545.2 122339-124366) | Unmethylation | — | 21q22.3 | 77.2 | 0.87 | 1028 | 42267649 | 42268676 | 5′-UTR and CDS | Similarity to human cDNA DKFZp586F0422 | |
| #77 (NT_00354.2 178197-181181) | Unmethylation | — | 21q22.3 | 72.0 | 0.96 | 1985 | 42323507 | 42325491 | 5′-UTR | Zinc finger protein 295 (ZNF295) | |
| #78 (NT_003545.2 387867-389371) | Unmethylation | — | 21q22.3 | 73.0 | 0.89 | 505 | 42533177 | 42533681 | 5′-UTR | ABCG1 gene for ABC transporter (ATP-binding cassette, sub-family G (WHITE) member 1 | |
| #79 (NT_003545.2 403601-405007) | Unmethylation | — | 21q22.3 | 72.4 | 1.01 | 407 | 42548911 | 42549317 | Intron | ABCG1 gene for ABC transporter (ATP-binding cassette, sub-family G (WHITE) member 1 | |
| #80 (NT_003545.2 665089-666509) | Unmethylation | — | 21q22.3 | 69.8 | 0.78 | 421 | 42810399 | 42810819 | 5′-UTR and CDS; 5′-UTR | TSGA2 mRNA for testis specific protein A2; putative glycerol 3-phosphate permease (SLC37A1) | |
| #81 (NT_003545.2 682430-684731) | Unmethylation | — | 21q22.3 | 72.8 | 0.83 | 1354 | 42827740 | 42829093 | 5′-UTR (exons -2, -1 and 1) | Putative glycerol 3-phosphate permease (SLC37A1) | |
| #82 (NT_003545.2 756256-760387) | Complete methylation | + | 21q22.3 | 61.2 | 1.12 | 3132 | 42901566 | 42904697 | — | ||
| #83 (NT_003545.2 822395-823837) | Unmethylation | — | 21q22.3 | 74.7 | 0.81 | 443 | 42967705 | 42968147 | 5′-UTR and CDS | Phosphodiesterase 9A (PDE9A) | |
| #84 (NT_003545.2 854975-856401) | Complete methylation | — | 21q22.3 | 62.3 | 0.86 | 427 | 43000285 | 43000711 | CDS | Phosphodiesterase 9A (PDE9A) | |
| #85 (NT_003545.2 1017136-1019217) | Complete methylation | + | 21q22.3 | 62.9 | 1.34 | 1082 | 43162446 | 43163527 | 3′-UTR | WD repeat domain 4 (WDR4) | |
| #86 (NT_003545.2 1047902-1049365) | Unmethylation | — | 21q22.3 | 70.6 | 0.87 | 464 | 43193212 | 43193675 | 5′-UTR and CDS | WD repeat domain 4 (WDR4) | |
| #87 (NT_003545.2 1142956-1145447) | Unmethylation | — | 21q22.3 | 76.2 | 0.96 | 1492 | 43288266 | 43289757 | 5′-UTR | Similarity to PBX/knotted 1 homeobox 1 | |
| #88 (NT_003545.2 1243354-1246655) | Incomplete methylation | — | 21q22.3 | 69.9 | 0.84 | 2302 | 43388664 | 43390965 | 5′-UTR | Cystathionine beta-synthase (CBS) | |
| #89 (NT_003545.2 1275925-1277810) | Unmethylation | — | 21q22.3 | 72.1 | 0.99 | 886 | 43421235 | 43422120 | 5′-UTR and CDS | U2(RNU2) small nuclear RNA auxillary factor 1 | |
| #90 (NT_002835.3 30733-32180) | Complete methylation | + | 21q22.3 | 60.4 | 1.07 | 448 | 43574697 | 43575144 | CDS | PR-domain zinc finger protein 15 (PRDM15) | |
| #91 (NT_002835.3 158046-161231) | Unmethylation | — | 21q22.3 | 76.1 | 0.86 | 2526 | 43702010 | 43704535 | 5′-UTR and CDS | Similarity to Mus musculus SNF1-like kinase (Snf1lk) | |
| #92 (NT_002835.3 297286-298768) | Complete methylation | — | 21q22.3 | 58.1 | 0.96 | 483 | 43841250 | 43841732 | 5′-UTR, CDS and 3′-UTR | H2B histone family member S (LOC115376) | |
| #93 (NT_002835.3 389981-391414) | Complete methylation | — | 21q22.3 | 69.5 | 0.91 | 434 | 43933945 | 43934378 | 5′-UTR and CDS | Heatschock transcription factor 2 binding protein (HSF2BP) | |
| #94 (NT_002835.3 391442-393133) | Unmethylation | — | 21q22.3 | 68.0 | 0.98 | 692 | 43935406 | 43936097 | 5′-UTR; 5′-UTR and CDS | Heatshock transcription factor 2 binding protein (HSF2BP); KIAA0179 protein | |
| #95 (NT_002835.3 450630-453100) | Incomplete methylation | — | 21q22.3 | 74.4 | 0.92 | 1471 | 43994594 | 43996064 | 5′-UTR and CDS | Pyridoxal (pyridoxine, vitamin B6) kinase (PDXK) | |
| #96 (NT_002835.3 473197-474680) | Complete methylation | + | 21q22.3 | 82.2 | 0.86 | 484 | 44017161 | 44017644 | CDS | Pyridoxal (pyridoxine, vitamin B6) kinase (PDXK) | |
| #97 (NT_002835.3 508085-509942) | Unmethylation | — | 21q22.3 | 72.9 | 0.94 | 858 | 44052049 | 44052906 | 5′-UTR and CDS | Cystatin B (stefin B) (CSTB) | |
| #98 (NT_002835.3 521399-523051) | Unmethylation | — | 21q22.3 | 71.6 | 0.90 | 653 | 44065363 | 44066015 | 5′-UTR and CDS | Novel nuclear protein 1 (NNP-1/Nop52) | |
| #99 (NT_002835.3 596448-599173) | Unmethylation | — | 21q22.3 | 80.4 | 0.84 | 1844 | 44140412 | 44142255 | 5′-UTR | Similarity to 1-acylglycerol-3-phosphate O-acyltransferase 3 | |
| #100 (NT_002835.3 743918-746243) | Unmethylation | — | 21q22.3 | 73.7 | 0.91 | 1442 | 44287766 | 44289207 | 5′-UTR and CDS | GT334 protein (GT334); transmembrane protein 1 (TMEM1) | |
| #101 (NT_002835.3 839100-840858) | Unmethylation | — | 21q22.3 | 70.4 | 0.99 | 759 | 44383064 | 44383822 | 5′-UTR and CDS | Periodic tryptophan protein 2 (PWP2) | |
| #102 (NT_002835.3 865543-867041) | Unmethylation | — | 21q22.3 | 69.5 | 0.81 | 499 | 44409507 | 44410005 | 5′-UTR and CDS | Chromosome 21 open reading frame 33 (C21orf33), homolog of ES1 protein (zebrafish) | |
| #103 (NT_002835.3 900040-901476) | Composite methylation | + | 21q22.3 | 53.0 | 0.92 | 437 | 44444004 | 44444440 | CDS | Chromosome 21 open reading frame 32 (C21orf32) | |
| #104 (NT_002835.3 972548-974376) | Unmethylation | — | 21q22.3 | 77.6 | 0.84 | 829 | 44516512 | 44517340 | 5′-UTR and CDS | KIAA0653 protein, Transmembrane protein B7-H2 ICOS ligand (B7-like protein) | |
| #105 (NT_002835.3 974194-975798) | Unmethylation | — | 21q22.3 | 71.4 | 0.79 | 605 | 44518158 | 44518762 | — | ||
| #106 (NT_002835.3 1017861-1019307) | Incomplete methylation | — | 21q22.3 | 75.1 | 0.83 | 447 | 44561825 | 44562271 | 5′-UTR and CDS | Autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) (AIRE) | |
| #107 (NT_002835.3 1031958-1033740) | Unmethylation | — | 21q22.3 | 79.3 | 0.89 | 783 | 44575922 | 44576704 | 5′-UTR | PFKL gene for liver-type 6-phosphofructokinase (EC 2.7.1.11) | |
| #108 (NT_002835.3 1070778-1072793) | Unmethylation | + | 21q22.3 | 76.2 | 0.85 | 1016 | 44614742 | 44615758 | 5′-UTR and CDS | Chromosome 21 open reading frame 2 (C21orf2) | |
| #109 (NT_002835.3 1082093-1084166) | Unmethylation | + | 21q22.3 | 76.6 | 0.87 | 1074 | 44626057 | 44627130 | — | ||
| #110 (NT_002835.3 1101487-1103181) | Complete methylation | + | 21q22.3 | 71.9 | 0.81 | 695 | 44645451 | 44646145 | CDS | Transient receptor potential channel 7 (TRPC7) | |
| #111 (NT_002835.3 1187382-1188869) | Unmethylation | — | 21q22.3 | 75.8 | 0.79 | 488 | 44731346 | 44731833 | — | ||
| #112 (NT_002835.3 1438369-1439902) | Composite methylation | + | 21q22.3 | 64.9 | 0.85 | 534 | 44982314 | 44982847 | Intron | Chromosome 21 open reading frame 29 (C21orf29) | |
| #113 (NT_002835.3 1441617-1443042) | Unmethylation | — | 21q22.3 | 62.4 | 0.79 | 426 | 44985562 | 44985987 | — | ||
| #114 (NT_002835.3 1533742-1535201) | Unmethylation | — | 21q22.3 | 73.2 | 0.91 | 460 | 45077687 | 45078146 | 5′-UTR and CDS | Ubiquitin-conjugating enzyme E2G2 (UBE2G2); homologous to yeast UBC7 | |
| #115 (NT_002835.3 1549573-1551858) | Unmethylation | — | 21q22.3 | 74.6 | 0.93 | 1286 | 45093518 | 45094803 | 5′-UTR | SMT3 (suppressor of mif two 3, yeast) homolog 1 (SMT3H1) | |
| #116 (NT_002835.3 1604933-1607527) | Unmethylation | — | 21q22.3 | 70.5 | 0.97 | 1595 | 45148878 | 45150472 | 5′-UTR and CDS | Pituitary tumor-transforming 1 interacting protein (PTTG1IP) | |
| #117 (NT_002835.3 1664660-1666157) | Unmethylation | — | 21q22.3 | 78.9 | 0.74 | 498 | 45208605 | 45209102 | Intron | Prediction gene 54 (PRED54) | |
| #118 (NT_002835.3 1671866-1673671) | Unmethylation | — | 21q22.3 | 70.3 | 1.00 | 806 | 45215811 | 45216616 | 5′-UTR | Chromosome 21 open reading frame 67 (C21orf67) | |
| #119 (NT_002835.3 1680257-1681681) | Complete methylation | + | 21q22.3 | 65.8 | 0.90 | 425 | 45224202 | 45224626 | Intron | Prediction gene 55 (PRED55) | |
| #120 (NT_002835.3 1710450-1712127) | Complete methylation | + | 21q22.3 | 72.7 | 1.07 | 678 | 45254395 | 45255072 | — | ||
| #121 (NT_002835.3 1750441-1752578) | Unmethylation | — | 21q22.3 | 75.4 | 0.81 | 1138 | 45294386 | 45295523 | — | ||
| #122 (NT_002835.3 1806394-1808604) | Unmethylation | — | 21q22.3 | 77.5 | 1.03 | 1211 | 45350339 | 45351549 | 5′-UTR | Double-stranded RNA-specific adenosine deaminase 2 (ADAR2) | |
| #123 (NT_002835.3 1865795-1867783) | Complete methylation | + | 21q22.3 | 67.2 | 0.85 | 989 | 45409731 | 45410719 | 5′-UTR and CDS | Double-stranded RNA-specific adenosine deaminase 2 (ADAR2) | |
| #124 (NT_002835.3 2020037-2021768) | Unmethylation | — | 21q22.3 | 75.5 | 0.79 | 732 | 45563914 | 45564645 | KIAA0958; chromosome 21 open reading frame 80 (C21orf80) | ||
| #125 (NT_002835.3 2077997-2079517) | Complete methylation | + | 21q22.3 | 54.7 | 0.77 | 521 | 45621843 | 45622363 | Intron | Prediction gene 59 (PRED59) | |
| #126 (NT_002835.3 2112166-2114090) | Complete methylation | + | 21q22.3 | 63.8 | 1.15 | 925 | 45656012 | 45656936 | — | ||
| #127 (NT_002835.3 2136861-2139459) | Unmethylation | — | 21q22.3 | 79.1 | 0.88 | 1599 | 45680707 | 45682305 | 5′-UTR and CDS | Collagen type XVIII alpha 1 (COL18A1) | |
| #128 (NT_002835.3 2274532-2276182) | Incomplete methylation | — | 21q22.3 | 77.8 | 0.84 | 651 | 45818349 | 45818999 | 5′-UTR (exons 1a, 1c, and 1b) | Reduced folate carrier (RFC1; SLC19A1) | |
| #129 (NT_002835.3 2286418-2288635) | Complete methylation | + | 21q22.3 | 75.0 | 0.79 | 1218 | 45830961 | 45832178 | — | ||
| #130 (NT_002835.3 2322402-2323845) | Composite methylation | — | 21q22.3 | 72.5 | 0.78 | 444 | 45866945 | 45867388 | — | ||
| #131 (NT_002835.3 2364595-2366958) | Complete methylation | + | 21q22.3 | 66.7 | 0.98 | 1364 | 45909214 | 45910577 | — | ||
| #132 (NT_002835.3 2371534-2374424) | Unmethylation | — | 21q22.3 | 76.3 | 0.89 | 1891 | 45918451 | 45920341 | — | ||
| #133 (NT_002835.32475023-2477222) | Complete methylation | + | 21q22.3 | 57.9 | 1.15 | 1200 | 46021940 | 46023139 | — | ||
| #134 (NT_002835.3 2653007-2655508) | Complete methylation | + | 21q22.3 | 54.8 | 1.25 | 1502 | 46199895 | 46201396 | Intron | Poly (rC)-binding protein 3 (PCBP3) | |
| #135 (NT_002835.3 2716963-2718791) | Complete methylation | + | 21q22.3 | 72.0 | 0.79 | 829 | 46263850 | 46264678 | CDS | Alpha-1 collagen type VI (COL6A1) | |
| #136 (NT_002835.3 2732562-2734239) | Complete methylation | — | 21q22.3 | 67.5 | 0.84 | 678 | 46279449 | 46280126 | CDS | Alpha-1 collagen type VI (COL6A1) | |
| #137 (NT_002835.3 2735023-2736682) | Complete methylation | + | 21q22.3 | 76.8 | 0.73 | 660 | 46281910 | 46282569 | — | ||
| #138 (NT_002835.3 2827157-2828726) | Unmethylation | — | 21q22.3 | 79.6 | 0.75 | 570 | 46374044 | 46374613 | 5′-UTR | Alpha-2 collagen type VI (COL6A2) | |
| #139 (NT_002835.3 2841396-2842933) | Complete methylation | — | 21q22.3 | 68.5 | 0.81 | 538 | 46388283 | 46388820 | CDS | Alpha-2 collagen type VI (COL6A2) | |
| #140 (NT_002835.3 2855101-2856552) | Complete methylation | — | 21q22.3 | 63.7 | 0.91 | 452 | 46401988 | 46402439 | CDS | Alpha-2 collagen type VI (COL6A2) | |
| #141 (NT_002835.3 2861362-2862966) | Complete methylation | — | 21q22.3 | 69.4 | 0.86 | 605 | 46408249 | 46408854 | CDS | Alpha-2 collagen type VI-a′ | |
| #142 (NT_002835.3 2890249-2891697) | Composite methylation | — | 21q22.3 | 70.8 | 0.77 | 449 | 46437137 | 46437585 | CDS and 3′-UTR | Similarity to Mus musculus adult male testis cDNA | |
| #143 (NT_002835.3 2957438-2959877) | Unmethylation | — | 21q22.3 | 73.6 | 0.75 | 1576 | 46504326 | 46505901 | 5′-UTR and CDS | Lanosterol synthase (2,3-oxidosqualene-lanosterolcyclase) (LSS) | |
| #144 (NT_002835.3 3014936-3016783) | Unmethylation | — | 21q22.3 | 69.5 | 0.95 | 848 | 46561824 | 46562671 | 5′-UTR and CDS | Minichromosome maintenance deficient 3 (S. cerevisiae)- associated protein (MCM3AP) | |
| #145 (NT_002835.3 3052859-3055543) | Unmethylation | — | 21q22.3 | 71.7 | 0.88 | 1955 | 46599747 | 46601701 | 5′-UTR and CDS | Pericentrin 2 (kendrin) (PCNT2) | |
| #146 (NT_002835.3 3132299-3134479) | Complete methylation | + | 21q22.3 | 58.0 | 1.07 | 1181 | 46679187 | 46680367 | Intron | Pericentrin, kendrin | |
| #147 (NT_002835.3 3187879-3189962) | Unmethylation | + | 21q22.3 | 75.3 | 0.77 | 1280 | 46734767 | 46736046 | — | ||
| #148 (NT_002835.3 3364581-3366420) | Unmethylation | — | 21q22.3 | 70.8 | 0.83 | 840 | 46911470 | 46912309 | 5′-UTR | HMT 1 (hnRNP methyltransferase, S. cerevisiae)-like 1 | |
| #149 (NT_002835.3 3396443-3398312)
|
Unmethylation
|
—
|
21q22.3
|
67.3
|
0.81
|
934
|
46943268
|
46944201
|
|
—
|
|
-
↵a The name in parenthesis for each CpG island indicates its symbol in URL (http://hgp.gsc.riken.go.jp/CGI/)
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↵b The plus (+) and minus (–) indicate the presence and absence of tandem repeat sequences, respectively
-
↵c The GC % indicates the GC-content of each CpG island
-
↵d The Obs/exp indicates the ratio of observed and expected CpG frequency
-
↵e The start and end point of each CpG island are shown using nucleotide positions in the sequence of human chromosome 21q in UCSC genome browser (http://genome.ucsc.edu/)
-
↵f The 5′-UTR (5′-untranslated region), CDS (coding region) and 3′-UTR (3′-untranslated region) indicate the location of the CpG island in its flanking gene
