A novel method for multiple alignment of sequences with repeated and shuffled elements

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 11.
Figure 11.

Comparison of blocks produced by TBA and ABA. A region on human genome surrounding the CAV2 gene is displayed on the “zoo genome” (NISC target region T1) of the UCSC genome browser (Kent et al. 2002). We use BLASTZ with parameters “B = 1 C = 2” to include reverse strand matches. Blocks of multiplicity greater than one are shown with shades of gray indicating the multiplicity of the blocks. Most of the blocks have multiplicity of three, corresponding to three-way alignments. Darker gray blocks indicate higher multiplicity and include duplications and inversions (matches on the reverse strands).

This Article

  1. Genome Res. 14: 2336-2346

Preprint Server