The functional genomics and proteomics pipeline. Starting with the large-scale production and molecular analysis of cDNAs, a human ORFeome resource is generated. This physical resource is systematically exploited in high-throughput applications of protein localization, cell-based assays, and proteomics applications. Information that is derived from these experiments is integrated with expression profiling data from clinical studies and external information to allow for an efficient mining of data. The output is functionally characterized genes and proteins with their possible disease relations. The results are presented through http://www.dkfz.de/LIFEdb.
