High-Throughput Generation of P. falciparum Functional Molecules by Recombinational Cloning

Table 2.

Immunogenicity of P. falciparum (Pf) Circumsporozoite Protein (PfCSP) and P. yoelii (Py) CSP DNA Constructs in VR1020 and VR1020-DV

Dose 2
Dose 3
PfCSP-VR1020 40 (0-160)a 2560 (0-120)a
PfCSP-VR1020-DV 40 (0-160)a 1280 (0-2560)a
PyCSP-VR1020 2560 (0-10,240)b 5120 (0-20,480)b
PyCSP-VR1020-DV 1280 (0-5120)b 2560 (0-5120)b
VR1020
0a,b
0a,b

  • Groups of 10 CD-1 mice were immunized ID with 100 μg of each DNA construct. Sera were collected 2 wks after doses 2 and 3.

  • ↵a Sera tested by IFAT on air-dried P. falciparum sporozoites.

  • ↵b Sera tested by IFA on air-dried P. yoelli sporozoites.

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  1. Genome Res. 14: 2076-2082

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