An ORFeome-based Analysis of Human Transcription Factor Genes and the Construction of a Microarray to Interrogate Their Expression

The number of transcription factor genes for S. cerevisiae, C. elegans, D. melanogaster, and H. sapiens is shown, divided by the approximate total number of genes for each organism, to estimate the percentage of the total gene content that transcription factor genes represent. Two estimates are given for H. sapiens, based on current gene predictions from Ensembl and NCBI. Transcription factor gene counts are the same as in Table 1. Total gene count sources are as follows: ^aSGD (July 2003), http://www.yeastgenome.org/VL-FAQ.html; ^bEnsembl C. elegans v19.102.1 (December 16, 2003), excluding 442 pseudogenes, http://www.ensembl.org/Caenorhabditis_elegans/stats/; ^cEnsembl D. melanogaster v19.3a.1 (January 7, 2003), http://www.ensembl.org/Drosophila_melanogaster/stats/; ^dNCBI human genome assembly build 34 (July 2003), http://www.ncbi.nlm.nih.gov/mapview/stats/BuildStats.cgi?taxid=9606&build=34&ver=1, and ^eEnsembl v19 build 34a (December 16, 2003), excluding 1744 pseudogenes, http://www.ensembl.org/Homo_sapiens/stats/.