Table 4.
Ratio of Synonymous to Nonsynonymous Substitutions
| Syn subs | Nonsyn subs | Total subs | Ratio S/NS | |
|---|---|---|---|---|
| All substitutions | 13,465 | 15,494 | 28,961 | 0.87 |
| SNP substitution | 5998 | 4453 | 10,451 | 1.35 |
| Non-SNP substitutions | 7467 | 11,041 | 18,508 | 0.68 |
| Both well-supported | 1505 | 1183 | 2688 | 1.27 |
| Support mRNA only | 548 | 752 | 1300 | 0.73 |
| Support genome only
|
3499
|
6215
|
9714
|
0.56
|
-
Ratios of synonymous to nonsynonymous substitutions detected by mRNA alignments to the human genome sequence are shown. Substitutions are classified into SNPs or non-SNPs based on inclusion in the dbSNP database. Well-supported substitutions imply that there are at least three additional transcript sequences supporting both the genome and mRNA sequence variants. For the last two cases in which only the mRNA or genome sequence variant is supported, we only require a single additional supporting transcript sequence.
