Predicting Subcellular Localization via Protein Motif Co-Occurrence

Table 5.

Prediction Accuracy of PSLT on Yeast and Mouse Proteins



Independent yeast data set test (second-best test)

Independent mouse data set test (second-best test)

Sensitivitya
PPVb
Sensitivitya
PPVb
ER 53 (64)% 65 (72)% 67 (78)% 53 (66)%
Golgi 37 (43)% 53 (79)% 70 (85)% 79 (85)%
Cytosol 55 (77)% 18 (35)% 75 (88)% 77 (89)%
Nucleus 73 (83)% 79 (88)% 91 (96)% 92 (97)%
Peroxisome 32 (50)% 30 (45)% 57 (71)% 80 (83)%
Plasma memb 72 (74)% 78 (84)% 71 (72)% 56 (79)%
Lysosome 40 (52)% 62 (88)% 77 (93)% 72 (87)%
Mitochondria 55 (64)% 70 (83)% 79 (89)% 86 (94)%
Extracellular 50 (50)% 25 (33)% 93 (97)% 93 (96)%
Overall accuracy 56 (71)% 84 (92)%
Coverage
53 (54)%
83 (83)%
  • a Sensitivity calculated as TP/(TP + FN).

  • b PPV : positive predictive value (calculated as TP/(TP + FP)).

This Article

  1. Genome Res. 14: 1957-1966

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