Predicting Subcellular Localization via Protein Motif Co-Occurrence

Table 2.

Prediction Accuray of PSLT on Human Proteins



Self-consistency test (second-best test)

10-fold cross validation test (second-best test)

Sensitivitya
PPVb
Sensitivitya
PPVb
ER 82 (95)% 93 (98)% 69 (82)% 83 (85)%
Golgi 84 (91)% 87 (98)% 60 (64)% 74 (81)%
Cytosol 90 (98)% 85 (96)% 65 (83)% 68 (78)%
Nucleus 96 (99)% 93 (97)% 93 (97)% 84 (93)%
Peroxisome 73 (94)% 89 (94)% 43 (64)% 50 (67)%
Plasma membrane 94 (98)% 86 (96)% 89 (91)% 77 (89)%
Lysosome 81 (96)% 90 (99)% 60 (71)% 71 (76)%
Mitochondria 88 (98)% 85 (97)% 67 (76)% 61 (72)%
Extracellular 95 (100)% 91 (99)% 89 (93)% 87 (91)%
Overall accuracy 90 (97)% 78 (86)%
Coverage
88 (88)%
74 (74)%
  • a Sensitivity calculated as TP/(TP + FN).

  • b PPV indicates positive predictive value (calculated as TP/[TP + FP]).

This Article

  1. Genome Res. 14: 1957-1966

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