Statistical Test of the Significance of Underrepresentation of Highly Correlated Gene Pairs in Ortholog Sets With Species-Specific Duplications
|
|
R > 0.6 |
R > 0.7 |
R > 0.8 |
R > 0.9 |
|---|---|---|---|---|
| Human duplication | 91% | 58% | 52% | 60% |
| p = 0.37 | p = 0.0042 | p = 0.0043 | p = 0.038 | |
| Mouse duplication | 61% | 48% | 36% | 24% |
|
|
p = 0.0111
|
p = 0.0027
|
p = 0.0015
|
p = 0.0018
|
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R indicates the correlation coefficient of gene expression between human and mouse, measured over 16 tissues. The percentages indicate the ratios between the fraction of genes having an R-value above the specified level in the set of orthologs where a species-specific duplication is present (163 sets for human and 139 for mouse) compared with the fraction in the set of 1325 orthologs where there have been no species-specific duplications. p-values were calculated from 10,000 Monte Carlo randomizations.
