Figure 1
Genes highly similar in expression are underrepresented in ortholog sets with recent human- or mouse-specific gene duplications. Histograms of expression correlation coefficients (R) across 16 tissues are shown for (A) 1325 one-to-one orthologs between human and mouse; (B) 163 ortholog sets with one mouse sequence and more than one human co-ortholog; (C) 135 ortholog sets with one human sequence and more than one mouse co-ortholog. Overlaid on each histogram are cumulative lines showing the proportion of ortholog sets having expression similarity lower than a particular value of R, for the one-to-one set (solid line), and for the sets with species-specific duplications (stars).
