Mouse Interchromosomal Fissionsa
|
Human fragment (Mb)b |
Breakpoints for mouse (Mb)c |
Mouse syntenic blocks (Mb) |
Breakpoints for rat (Mb)d |
Rat syntenic blocks (Mb) |
|---|---|---|---|---|
| H2 (10.7-52) | 26.3, 29 | M12 (17.3-3.1, tipe), M5 (28.4-30.7), M17 (70-90.5) | 35 | R6 (41.2-18.8) and (0.3-16.7, tipf) |
| H5 (8.9-96.2) | 43 | M15 (32.6-3.1, tip), M13 (116.2-70.8, endg) | 87.18, 87.47 | R2 (85.2-1.4) with a 400 kb inversion |
| H5 (154.3-173.5) | 171.5, 172.6 | M11 (55.5-33), M17h (25.2-25.5), M11 (31.7-32.2) | R10 (34-15.8) | |
| H5 (98.5-109.9) | 101.5, 102.8 | M1 (94.3-97) and (98.6-97.7), M17 (57.3-63.8) | R9 (93.6-104.3) | |
| H6 (150-171) | 155, 159, 159.4, 165, 170 | M10 (3.2-7.1, tip), M17 (6-3, tip), 7.24-7.05), (12.2-8.4), (6.7-7) and (13.8-14) | R1 (34.2-54) | |
| H6 (39.3-52.4) | 49 | M17 (48.2-39.6), M1 (18.5-21.1) | R9 (6.3-19.8) | |
| H7 (76.3-97) | 85, 92.2 | M5 (19.6-10.8) and (3.2-10.5, tip), M6 (3.1-7.4, tip) | R4 (9.3-32) with 148 kb inversion in the middle | |
| H8 (51.8-62.3) | 56.3 | M1 (7.7-3.1, tip), M4 (3.0-9.1, tip) | R5 (10.8-23.55) with 17 kb inversion in the middle | |
| H10 (0.5-27) | 6, 15.5 | M13 (9.4-3.3, tip), M2 (11.7-3.4, tip), and (12.1-23.1) | R17 (71.6-96.5, end) | |
| H11 (58.5-71.4) | 63, 64.4, 69 | M19 (12-7.8), (3.8-3.0, tip) and (3.99-6.8), M7 (133.7-132.8, end)i | R1 (214-204.8) | |
| H16 (0.3-15.9) | 3.2 | M17 (24.8-22.2), M16 (3.1-13.9, tip) | R10 (15.4-0) | |
| H21 (42.5-47) | 44 | M17 (29.7-30.7), M10 (78-76) | R20 (9.4-12.8) | |
| H22 (27.5-30.8)
|
30.6
|
M11 (5.4-3.0, tip), M5 (31.2-31.4)
|
|
R14 (86.2-83.5)
|
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↵a All blocks shown are above 100 kb and with >3 BACs.
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↵b Each human fragment (indicated in parentheses) corresponds to a region in a single rat chromosome, but is syntenic to fragments from multiple mouse chromosomes. For instance, the first 27 Mb of H10 (0.5-27 Mb) broke twice, forming one syntenic block to M13's initial 6 Mb and two blocks in opposite direction to M2's initial 20 Mb, whereas it corresponded to R17's last 25 Mb as a single piece. In some cases, rat has an inversion, but still remains less rearranged (e.g., the H2/R6/M12/M5/M17 synteny). Only one exception was found where H10 (74.8-81.2 Mb) broke at 79.6 Mb to R15 (4.2-0 Mb) and R16 (0-1.4 Mb), whereas it was continuous for M14 (15.3-21 Mb).
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↵c Breakpoints on the human genome.
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↵d Breakpoints on the human genome.
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↵e Tip: the beginning of euchromatic sequences of the chromosomes, which starts at 3 Mb in the mouse assembly and 1 bp in the rat assembly. The tip is near the centromeric region in each mouse chromosome, and has been identified at the fission-related breakpoints for 13 mouse chromosomes.
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↵f Tip: the beginning of euchromatic sequences of the chromosomes, which starts at 3 Mb in the mouse assembly and 1 bp in the rat assembly. The tip is near the centromeric region in each mouse chromosome, and has been identified at the fission-related breakpoints for 13 mouse chromosomes.
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↵g End: the end of euchromatic sequences of the chromosomes in the assembly.
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↵h M17 was involved in seven of the 13 total fissions identified. The M11/M17/M11 breakages are likely due to a translocation.
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↵i M19 and M7 seem to have evolved from an ancestral chromosome closer to an R1q fragment through fission. Except for several inversions mostly associated with this fission event, no reorganizations were found in them.
