Human, Mouse, and Rat Genome Large-Scale Rearrangements: Stability Versus Speciation

Table 2.

Mouse/Rat Rearrangement Breakpoints on the Human Genomea


M-Inter R-Inter

M-Intra R-Intra

M-Inter R-Intra

M-Intra R-Inter

M-Inter

R-Inter

M-Intra

R-Intra
130b
125b
6
5
14c
1d
21e
46f
  • a All breakpoints identified are incorporated. M-Inter R-Inter: shared interchromosomal breakpoints. M-Intra R-Intra: shared intrachromosomal breakpoints. M-Inter R-Intra: shared breakpoints, interchromosomal for mouse and intrachromosomal for rat. M-Inter: mouse-specific interchromosomal breakpoints.

  • b About 58 are due to human specific intrachromosomal rearrangements.

  • c All 14 breakpoints are described in details in Table 3.

  • d R15/R16 fission, the only exception for the mouse fissions described in Table 3.

  • e Eight are associated with M-Inter (mouse fission related inversions) as described in Table 3, involving syntenic blocks of >100 kb and with >3 BACs.

  • f A total of 14 are due to inversions in R1p, R11, R19, R20, R10/M11/H17 as described in Table 4, involving synteny blocks of >100 kb and with >3 BACs; 30 involve simple inversions in the middle of the human/mouse syntenic blocks.

This Article

  1. Genome Res. 14: 1851-1860

Preprint Server