Cover image

Cover Mature microRNAs are known to be processed from precursor RNA sequences resembling 'hairpin' secondary structures caused by Watson--Crick or G/U base pairings. A human figure comprised of hairpins is representative of the significant number of microRNA genes present in the mammalian genome. In this issue, a comprehensive picture of mammalian microRNA transcription is provided by systematically determining their map position and orientation in relation to genes and transcripts in the human and mouse genomes, respectively. (Initial cover idea by M. Warren and N. Taylor. Cover design by Together Design, London, United Kingdom. [For details, see Rodriguez et al., pp. 1902–1910])