Figure 2
Most significantly conserved motifs are highly enriched in known TF binding sites. (A) The distribution of network-level conservation significance (-Log10(p)) for a set of 10,000 random motifs. The median value for the 48 known TF binding sites is 4.5 (vertical dashed line). A representative set of conserved known TF binding sites is highlighted on the tail of the distribution. (B) The fraction of strong matches to known TF binding sites in a 2000 wide sliding window across the entire P-value distribution of all the 80,000 secondary motifs.
