Identification of Antibiotic Stress-Inducible Promoters: A Systematic Approach to Novel Pathway-Specific Reporter Assays for Antibacterial Drug Discovery

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Figure 2
Figure 2

Alignment of the conserved putative transcription factor binding sites present in the genomic upstream sequences of five yjaX-coregulated transcriptional units. Nucleotide-specific coloring of the aligned residues was applied for sites with >80% conservation. Underneath, a sequence logo representation displays the information content per aligned site. Note the clear palindromic symmetry of the motif, indicating that a dimeric transcription factor binds to these DNA sites, which implies a role as cis-acting recognition motifs for the regulation of the Bacillus subtilis type II fatty acid biosynthesis pathway.

This Article

  1. Genome Res. 14: 90-98

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