Tissue Specificity of Gene Expression Correlates Positively With Higher Evolutionary Rates (Median Values of KA, KS, and KA/KS), the Fraction of Genes Whose Products Are Secreted (fsec) and the Fraction of Genes That are Linked to Disease (fdis)
|
Partition |
maxTS range |
Gene number |
Median maxTS |
Median KA/KS |
Median KA |
Median KS |
fsec (%) |
fdis (%) |
fLe (%) |
fAll (%) |
fLe/fAll (%) |
K-S test probability |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | ≤0.1 | 1571 | 0.082 | 0.059 | 0.034 | 0.530 | 14.3 | 9.2 | 7.6 | 34.8 | 22.0 | 1.4 × 10-4, 1.2 × 10-5, 7.2 × 10-7, 2.2 × 10-16, 2.0 × 10-3, 3.8 × 10-4, 2.2 × 10-16 |
| 2 | 0.1—0.2 | 2074 | 0.133 | 0.070 | 0.043 | 0.574 | 21.9 | 11.9 | 5.3 | 27.1 | 19.4 | |
| 3 | 0.2—0.3 | 645 | 0.243 | 0.078 | 0.054 | 0.594 | 32.7 | 12.5 | 2.3 | 18.5 | 12.6 | 9.1 × 10-2, 7.9 × 10-9 |
| 4 | 0.3—0.4 | 294 | 0.335 | 0.090 | 0.063 | 0.658 | 37.4 | 15.0 | 1.0 | 15.3 | 6.7 | 5.8 × 10-4 |
| 5
|
≥0.4
|
376
|
0.530
|
0.126
|
0.089
|
0.655
|
45.5
|
25.8
|
0.8
|
11.2
|
7.1
|
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|
-
Tissue specificity correlates negatively with fLe/fAll, which represents the under- or over-representation of embryonic or larval lethality phenotypes in the nematode worm mapped to the tissue-specificity partition of their likely human ortholog (see Results). The Kolmogorov-Smirnov (K-S) test probability (see Methods) represents the likelihood that the KA/KS distribution of genes in a lower partition differs from those distributions in higher partitions.
