Elevated Rates of Protein Secretion, Evolution, and Disease Among Tissue-Specific Genes

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Figure 2
Figure 2

Evolutionary constraints on mouse tissues have been constant since the divergence of human and rodent lineages (∼75 million years ago). Median KA/KS values have been calculated for mouse tissue-specific genes using the yn00 method of Yang and Nielsen (2000; see Table 4). The 1:1 rat–mouse and human–mouse orthology relationships were obtained from Ensembl's Compara database.

This Article

  1. Genome Res. 14: 54-61

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