CONREAL: Conserved Regulatory Elements Anchored Alignment Algorithm for Identification of Transcription Factor Binding Sites by Phylogenetic Footprinting

Table 2.

Conservation of TFBSs from the Reference Set Among Different Organisms Identified by Different Approaches


Site

Human

Mouse

Rat

Fugu

Zebrafish
R11477 Ref ALC ALC --C ALC
R08296 Ref --C --- n/a ---
R08092 Ref --C --- --- ---
R10227 Ref A-C ALC --- n/a
R11626 Ref -LC ALC --- --C
R08293 Ref -L- --C n/a --C
R03187 Ref ALC -LC n/a n/a
R13001 Ref -LC --- n/a n/a
R13048 Ref --C --- --- ---
R11015 ALC Ref ALC --- --C
R08112 ALC ALC Ref --- --C
R08512
ALC
ALC
Ref
--C
-LC
  • Analysis parameters: 75% PWM threshold, 50% homology threshold, 5-bp flank length. (Ref) the site is a reference in the given organism, that is, known to be functional; (A) found by AVID; (L) found by LAGAN; (C) found by CONREAL; (-) not found; (n/a) the reference gene does not have an annotated ortholog in a given organism. The complete and detailed dataset is available as Supplemental Table S3.

This Article

  1. Genome Res. 14: 170-178

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