Table 4.
Comparison of the Fine Mapping of a Founder Mutation Using Case Haplotypes, Case Genotypes With Strategy A, and That With Strategy B for 100 Simulated Complex Disease Data Sets
|
Strategy |
#Successesa |
Mean(pos) |
Std(pos) |
Mean 95% PI width |
RMSE |
Size of cluster 1c |
|---|---|---|---|---|---|---|
| Phase known | 42 | 0.8852 | 0.0940 | 0.3389 | 0.0930 | 19.85 |
| A | 33 | 0.8489 | 0.0818 | 0.3299 | 0.0863 | 20.33 |
| Bb
|
41
|
0.9081
|
0.0926
|
0.3401
|
0.0957
|
20.41
|
-
↵a The number of times that the method is successful, i.e., the 95% PI covers the true location and also has a width no greater than 25% of the whole region (1.73 cM).
-
↵b Phased by HAPLOTYPER.
-
↵c Average number of haplotypes being sorted into cluster 1. The total number of disease haplotypes is 50, of which 15 are the mutation-carrying haplotypes.
