Table 3.

Comparison of Strategies A and B for Estimating the AD Locus From the APOE Data Set

Data Set	Strategy	Position^a	95% PI width	Size of cluster 1^b
All 30 markers	A	0.4366	0.0283	82
	B	0.4272	0.0168	95
29 markers without APOE-4	A	0.4269	0.0299	62
	B	0.4247	0.0149	106

↵a The true APOE-4 location is at 425 kb, corresponding to 0.425 cM.
↵b The number of haplotypes assigned to cluster 1 (the mutation-taking cluster). The total number of disease haplotypes was 372.

Haplotype Information and Linkage Disequilibrium Mapping for Single Nucleotide Polymorphisms