Pleiotropy, Homeostasis, and Functional Networks Based on Assays of Cardiovascular Traits in Genetically Randomized Populations

Table 1.

CV Trait Mean, Standard Deviation and Sample Size in A/J, C57BL/6J and AXB/BXA RI Strains

Strain
N
Stat
PWTh
SWTh
EDD
ESD
FS
LV Mass
BW
LV/BW
TH/R
SV
HR
EST
CO
A/J mean 0.46 0.47 2.91 1.61 50.66 43.00 22.70 1.88 0.31 28.16 462.00 6.61 12.85
SD 0.08 0.07 0.36 0.56 11.18 11.54 3.13 0.36 0.03 7.60 75.10 2.74 3.25
n 44 44 44 44 44 44 39 39 44 44 10 44 10
C57BL/6J mean 0.51 0.50 3.36 1.98 43.49 53.24 23.50 2.27 0.30 34.24 420.00 13.56 14.27
SD 0.05 0.06 0.40 0.46 10.84 9.80 3.92 0.26 0.05 6.29 40.00 3.72 2.42
n 44 44 44 44 44 44 44 44 44 44 10 44 10
AXB1 23 mean 0.59 0.59 3.34 1.85 44.63 58.75 25.78 2.29 0.35 31.52 422.61 9.23 13.24
SD 0.08 0.09 0.33 0.32 7.26 15.48 4.73 0.54 0.06 9.39 51.89 4.85 3.82
AXB2 18 mean 0.54 0.52 3.23 1.57 51.54 49.08 21.00 2.31 0.33 30.32 528.33 13.40 15.9
SD 0.04 0.04 0.30 0.29 5.55 10.27 3.74 0.36 0.03 8.60 67.58 5.81 4.26
AXB4 14 mean 0.53 0.47 2.67 1.11 58.44 32.54 16.86 1.92 0.37 18.02 537.86 3.14 9.77
SD 0.08 0.06 0.23 0.20 6.54 8.63 2.96 0.34 0.05 4.50 67.05 1.13 2.86′
AXB5 27 mean 0.56 0.56 3.02 1.47 51.58 46.88 21.30 2.22 0.37 24.85 475.56 11.69 11.74
SD 0.06 0.08 0.32 0.29 6.59 14.47 3.02 0.64 0.04 7.67 88.72 4.82 4.05
AXB10 18 mean 0.55 0.55 3.14 1.71 46.23 49.18 21.17 2.33 0.35 26.50 523.33 12.74 13.72
SD 0.06 0.07 0.38 0.43 8.65 15.07 2.41 0.70 0.03 7.83 67.65 2.76 4.21
AXB11 9 mean 0.58 0.56 3.19 1.60 50.61 52.38 31.67 1.64 0.37 29.89 446.67 9.16 12.62
SD 0.07 0.06 0.55 0.52 10.60 16.64 6.65 0.31 0.09 13.93 94.21 4.51 5.07
AXB12 19 mean 0.50 0.50 3.20 1.76 44.12 45.74 23.24 1.94 0.30 28.87 417.09 5.07 12.2
SD 0.07 0.07 0.43 0.35 7.44 9.57 4.61 0.34 0.05 6.42 98.32 2.41 4.17
AXB15 22 mean 0.62 0.63 3.15 1.51 52.05 57.30 29.50 2.00 0.40 28.10 455.45 9.34 12.79
SD 0.08 0.10 0.26 0.26 7.63 12.30 5.97 0.51 0.08 7.06 72.69 2.95 3.8
AXB18 24 mean 0.58 0.57 3.38 1.84 46.68 57.96 24.09 2.41 0.35 32.97 470.63 9.23 15.31
SD 0.05 0.04 0.49 0.57 10.01 13.80 4.10 0.40 0.07 11.22 72.39 2.64 5.31
AXB24 13 mean 0.53 0.54 2.93 1.46 50.46 42.11 28.46 1.47 0.37 22.94 461.54 10.61 10.42
SD 0.06 0.07 0.38 0.30 5.06 13.99 6.16 0.33 0.05 8.53 49.81 3.32 3.41
BXA1 6 mean 0.58 0.58 3.30 2.06 37.50 54.87 28.00 1.98 0.35 27.15 405.00 8.82 11.26
SD 0.04 0.05 0.22 0.24 4.44 5.70 3.74 0.28 0.04 5.47 79.94 2.06 4.63
BXA2 12 mean 0.48 0.51 3.25 1.57 51.87 44.66 26.42 1.71 0.31 31.55 490.00 9.43 15.61
SD 0.06 0.06 0.37 0.24 3.87 12.32 3.70 0.47 0.04 10.52 34.64 2.54 5.75
BXA4 8 mean 0.48 0.49 3.05 1.50 48.60 44.13 24.06 1.71 0.30 29.33 488.42 5.43 14.58
SD 0.10 0.10 0.67 0.35 9.20 14.21 4.38 0.49 0.07 11.15 78.97 3.06 6.21
BXA7 10 mean 0.51 0.51 3.08 1.69 45.17 42.38 25.70 1.67 0.33 24.44 540.00 5.68 13.19
SD 0.06 0.04 0.25 0.32 8.11 8.83 4.08 0.31 0.03 5.59 63.25 1.85 3.4
BXA8 11 mean 0.59 0.58 2.95 1.36 54.31 46.77 26.45 1.79 0.40 23.72 540.00 6.13 12.75
SD 0.03 0.04 0.30 0.28 5.60 7.80 5.22 0.27 0.05 6.82 37.95 1.36 3.43
BXA12 10 mean 0.50 0.51 3.01 1.60 48.40 39.97 23.05 1.75 0.35 23.60 499.50 5.87 11.43
SD 0.05 0.05 0.45 0.56 11.44 9.21 4.18 0.35 0.07 7.80 74.85 1.96 2.99
BXA14 15 mean 0.61 0.61 3.36 1.72 49.10 62.01 26.93 2.31 0.36 33.60 504.00 4.76 16.7
SD 0.04 0.04 0.36 0.36 6.97 15.50 4.27 0.43 0.03 9.90 98.33 1.57 5.24
BXA16 9 mean 0.48 0.48 3.19 1.69 47.08 41.52 23.00 1.83 0.30 27.59 440.00 5.98 12.2
SD 0.05 0.04 0.19 0.23 5.59 7.50 4.18 0.29 0.03 4.97 67.08 2.06 3.1
BXA24 19 mean 0.55 0.52 3.76 2.40 36.09 63.06 26.32 2.41 0.29 39.43 348.95 5.37 13.62
SD 0.07 0.06 0.28 0.30 5.46 9.68 3.56 0.34 0.04 8.37 62.62 2.98 3.23
BXA25 19 mean 0.53 0.53 2.94 1.45 50.94 40.89 27.26 1.51 0.36 22.84 473.68 4.99 10.77
SD 0.06 0.05 0.29 0.24 4.89 8.23 4.81 0.23 0.05 6.32 68.98 1.56 3.26
BXA26 29 mean 0.53 0.52 3.16 1.74 45.58 46.87 23.80 1.93 0.34 27.46 458.28 6.43 12.65
SD
0.06
0.06
0.52
0.50
8.68
18.22
4.07
0.49
0.05
13.21
77.28
2.65
6.24

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  1. Genome Res. 13: 2082-2091

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