A General Approach for Identifying Distant Regulatory Elements Applied to the Gdf6 Gene

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Figure 1
Figure 1

A 2.7-kb region upstream of the Gdf6 gene drives neural tube expression but not limb joint expression in transgenic mouse embryos. Top: diagram of the p2.7βgeo construct. The LacZ* denotes the LacZ/neo fusion gene plus polyA signal. Bottom: Side (left) and dorsal (right) views of a 14.5-dpc mouse embryo transgenic for p2.7βgeo. Arrowheads indicate staining in the dorsal neural tube. Arrow indicates forebrain expression.

This Article

  1. Published in Advance January 1, 2003, doi: 10.1101/gr.1306003 Genome Res. 13: 2069-2081

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