Neocentromeres in 15q24-26 Map to Duplicons Which Flanked an Ancestral Centromere in 15q25

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Figure 1
Figure 1

Partial karyotypes in a, b, and c show FISH results of markers F, G, and E, respectively, on humans chromosomes 14 or 15 (left) and on PHA7 (right). Note that probe E (c), giving a single signal at HSA15q25, yielded signals on both sides of PHA7 centromere. (d) Diagram summarizing the fission event that disrupted the ancestral 14/15 association, giving rise to chromosomes 14 and 15. C, centromere; NC, neocentromere; AC, ancestral centromere. (e–i) Examples of FISH results using probe RP11-152F13 on human and great apes chromosome XV (e–g), and on two OWMs (h–i). See text for details.

This Article

  1. Published in Advance January 1, 2003, doi: 10.1101/gr.1155103 Genome Res. 13: 2059-2068

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