Automated Detection of Informative Combined Effects in Genetic Association Studies of Complex Traits

Table 4.

Selection Frequency of Main Effects and Interactions by DICE on 100 Bootstrap Replicates of the SELP Dataset Using the Codominant Coding Scheme


Main effect

Selection frequency

First-order interaction

Selection frequency

Second-order interaction

Selection frequency
T715P 61 T715P*T741T 46 S290N*N562D*V599L 52
N562D 18 S290N*N562D 44 S290N*N562D*C-2123G 13
T741T 6 country*T-1817C 19 S290N*N562D*T741T 10
T-1817C 4 V599L*T715P 16 S290N*N562D*-485I/D 6
-485I/D 4 N562D*-485I/D 15 N562D*T-1817C*T741T 5
A-1969G 3 country*N562D 15 N562D*C-2123G*V599L 5
V599L 2 N562D*T-1817C 13 S290N*N562D*A-1969G 4
S290N 1 country*T715P 11 N562D*V599L*A-1969G 4
C-2123G 1 country*C-2123G 11 N562D*V599L*C-2123G 4


N562D*T715P
10
country*S290N*N562D
4
  • n = 1147. The first 10 ranked interactions are shown. In bold are the effects selected in the original dataset

This Article

  1. Genome Res. 13: 1952-1960

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