Allele-Specific Holliday Junction Formation: A New Mechanism of Allelic Discrimination for SNP Scoring

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Figure 3
Figure 3

An extra mismatch is required to achieve allele-specific Holliday Junction formation. (A) Various mismatches inhibit branch migration to a different extent in 67-bp amplicons as judged by relative intensity of their HJ bands. (B) Effect of an extra mismatch (mm1) on Holliday Junction formation by various types of mismatches in very short (67-bp) amplicons.

This Article

  1. Genome Res. 13: 1754-1764

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