Allele-Specific Holliday Junction Formation: A New Mechanism of Allelic Discrimination for SNP Scoring

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Figure 1
Figure 1

Mismatch-induced Holliday Junction formation. (A) A single-base mismatch between two partial duplexes impedes branch migration and causes the stabilization of the Holliday Junction formed between the two partial duplexes through the annealing of their complementary tails. (B) Illustration of partial duplex and Holliday Junction formation by using PCR.

This Article

  1. Genome Res. 13: 1754-1764

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