Comparative Complete Genome Sequence Analysis of the Amino Acid Replacements Responsible for the Thermostability of Corynebacterium efficiens

Table 4.

Biased Amino Acid Substitutions in the Orthologous Genes of C. glutamicum and C. efficiens


C. glutamicum

C. efficiens

Forward

Reverse

Pointa

G + C changing by one-base substitution
Lys Arg 2855 664 1095.5 AAA → AGA, AAG → AGG
Ser Ala 3378 2372 503 TCA → GCA, TCC → GCC, TCG → GCG, TCT → GCT
Ser Thr 2623 1723 450
Ile Val 4332 3585 373.5 ATA → GTA, ATC → GTC, ATT → GTT
Asn Arg 978 372 303
Gln Glu 1321 747 287
Ile Leu 2191 1642 274.5 ATA → CTA, ATC → CTC, ATT → CTT
Ser Gly 1013 610 201.5 AGC → GGC, AGT → GGT
Lys Thr 600 235 182.5 AAA → ACA, AAG → ACG
Ala
Pro
1019
656
181.5

  • a Point is defined as the difference between the number of amino acid substitutions from C. glutamicum to C. efficiens and the number of substitutions in the opposite direction, divided by 2. All of the asymmetrical amino acid substitutions showed probability of obtaining the observed deviation from 50:50 by chance less than 0.001

This Article

  1. Genome Res. 13: 1572-1579

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