
Classification tree (Family C). An unrooted tree was constructed for 11 GPCRs. The scale bar indicates a maximum likelihood branch length of 0.1 inferred substitutions per site. GPCRs that have cognate ligands are distinguished in colored subgroups. Orphan GPCRs are shown in uncolored branches, and novel genes are indicated with black circles. Abbreviations are shown in Supplementary Information 4.











