Table 3.
Zinc Finger Protein Clusters Generated by All-Against-All BLAST Analysis
|
Clusters |
Domains |
Description |
Proteins |
|---|---|---|---|
| Cluster 1 | C2H2/KRAB/BTB | Transcriptional regulators with C2H2 core-binding domain | 296 |
| Cluster 2 | C4 zinc finger | Steroid hormone receptors | 44 |
| Cluster 3 | BTB/POZ/Kelch repeat | Actin-binding proteins | 35 |
| Cluster 4 | RING-CH/B-box/coiled coil | Tripartite motif family | 26 |
| Cluster 5 | Three C2H2 zinc finger | Sp/Krüppel-like factor family | 25 |
| Cluster 6 | LIM/Homeobox | LIM/homeobox family | 18 |
| Cluster 7 | RING-H2 | E3 ubiquitin-ligase family | 14 |
| Cluster 8 | Four LIM domains | Four and a half LIM domain family | 14 |
| Cluster 9 | Protein kinase C/Ser/Thr-type protein kinases | Protein kinase C | 12 |
| Cluster 10 | C5HC2/JmJN | Jumonji family | 7 |
| Cluster 11 | FYVE/PH | FYVE family | 7 |
| Cluster 12 | RING-CH/B-box/coiled coil/fibronactin type III | B-box family | 6 |
| Cluster 13 | Three LIM domain | Ajuba family | 6 |
| Cluster 14 | C1/Rho/GAP | Myosin IX family | 6 |
| Cluster 15 | GATA type zinc finger | GATA family | 6 |
| Cluster 16 | Four N-terminal C2H2 and two C-terminal C2H2 | Ikaros family | 5 |
| Cluster 17 | TRAF/RING-CH/MATH | TNF-receptor-associated factors | 5 |
| Cluster 18 | C2/PH/Btk | Ras GTPase family | 5 |
| Cluster 19 | Zinc finger ZZ | Dystrophin family | 5 |
| Cluster 20 | C1/PHD/EF hand/DAGKc/GAGka | Diacylglycerol kinase family | 5 |
| Cluster 21 | PHD | Chromatin regulator family | 5 |
| Cluster 22 | C2H2/Homeodomain | Transcription factors developmentally related | 4 |
| Cluster 23 | One N-terminal C2H2, six central C2H2, two C-terminal C2H2 | Novel C2H2 family (NFTR) | 4 |
| Cluster 24 | RING-H2/PA | G1-related family | 4 |
| Cluster 25 | SET/Chromodomain | Heterochromatin component proteins family | 4 |
| Cluster 26 | MIZ/Sap | Inhibitor of STAT family | 4 |
| Cluster 27 | NHL repeat/EGF | Oz/ten-m homolog family | 4 |
| Cluster 28 | RING-CH/C2H2 zinc finger | Novel C2H2/RING finger family | 4 |
| Cluster 29 | RING-CH/WWE | Deltex family | 4 |
| Cluster 30 | PHD finger | Novel PHD-containing family | 4 |
| Cluster 31 | LIM/PDZ | C-terminal LIM domain family | 4 |
| Cluster 32 | Two PHD finger | Novel PHD-containing family | 4 |
| Cluster 33 | CXXC finger/PHD/FYRN/bromodomain/SET | Chromatin regulator family | 4 |
| Cluster 34 | C2H2 zinc finger/PH | Forkhead-related transcription factors | 4 |
| Cluster 35 | C3H1 zinc finger/RNA recognition domain | U2 small nuclear ribonucleoprotein auxiliary factor | 4 |
| Cluster 36 | Three C2H2 C-terminal zinc fingers | EGR family | 4 |
| Cluster 37 | Tyr Kinase/Sh2/Sh3/Btk/PH | Tyrosine protein kinase BTK family | 4 |
| Cluster 38 | RING-CH | Polycomb family | 4 |
| Cluster 39 | C2H2 zinc finger/Gag-p24 | Gag family | 3 |
| Cluster 40 | Three C2H2 zinc fingers | Novel C2H2 family | 3 |
| Cluster 41 | ArfGap/PH | Centaurin family | 3 |
| Cluster 42 | RHO/BTB | Novel BTB family | 3 |
| Cluster 43 | DHHC zinc family | DHHC family | 3 |
| Cluster 44 | Fourteen C2H2 zinc finger | Novel C2H2 family | 3 |
| Cluster 45 | GCS-type zinc finger/Arfgap/Ank repeat | GCS-type zinc finger family | 3 |
|
Cluster 46
|
GATA/SANT/ELM2/BAH
|
Metastasis-associated proteins
|
3
|
