Phylogenetic tree for calcium-activated chloride channels (CLCAs). We included all the known mouse and human members of this family. PA2376 Cx43 Connexin was used as an outgroup. ClustalX was used to generate all the alignments of amino acid sequences. The following entries were analyzed: MmmCLCA1 PB18915 gp=NP_085104 ri E030034K24 chloride channel calcium activated 1; mCLCA2 gi 13447394 ref NP_085104.1 chloride channel calcium activated 2 [Mus musculus]; mCLCA3 PB6141 gp=NP_059502 chloride channel calcium activated 3; mCLCA4 gi 15822539 gb AAG23712.1 calcium-activated chloride channel CLCA4 [Mus musculus]; PC22092 ri=4732440A06 cdslen=2829 similar to CALCIUM-ACTIVATED CHLORIDE CHANNEL-2 [Homo sapiens]; TF23815 9130020L07 ORF:32..2809 Frame +2; hCLCA1 gi 20538010 ref XP_030657.4 calcium activated chloride channel 1 precursor [Homo sapiens]; hCLCA2 gi 5729769 ref NP_006527.1 calcium-activated chloride channel 2 precursor [Homo sapiens]; hCLCA3 gi 4757998 ref NP_004912.1 calcium-activated chloride channel 3 precursor [Homo sapiens]; hCLCA4 gi 20538007 ref XP_030654.4 calcium-activated chloride channel 4 [Homo sapiens]; PA2376 spid=P23242 GAP JUNCTION ALPHA-1 PROTEIN (CONNEXIN 43) (CX43).
