Phylogenetic tree for family 3 GPCRs. We included all the proteins that contain the InterPro Entry IPR000337, with the exception of members of the vomeronasal receptors V3Rs that were recently reclassified as V1rd (Rodriguez et al. 2002). PA2376 Cx43 Connexin was used as an outgroup. ClustalX was used to generate all the alignments of amino acid sequences. The following entries were analyzed: Mm-PC36669 ri=C630030A14 hypothetical protein; Mm-PC22772 ri=5330439C02 hypothetical protein; Hs-gi 22054841 ref XP_168702.2 similar to agCP15215 [Homo sapiens; Hs-mGluR1 gi 2495074 sp Q13255 MGR1_HUMAN Metabotropic glutamate receptor 1 precursor; Hs-mGluR2 gi 2495075 sp Q14416 MGR2_HUMAN Metabotropic glutamate receptor 2 precursor; Hs-mGluR3 gi 2495076 sp Q14832 MGR3_HUMAN Metabotropic glutamate receptor 3 precursor; Hs-mGluR4 gi 2495077 sp Q14833 MGR4_HUMAN Metabotropic glutamate receptor 4 precursor; Hs-mGluR5 gi 1709020 sp P41594 MGR5_HUMAN Metabotropic glutamate receptor 5 precursor; Hs-mGluR6 gi 3024134 sp O15303 MGR6_HUMAN Metabotropic glutamate receptor 6 precursor; Hs-mGluR7 gi 2495078 sp Q14831 MGR7_HUMAN Metabotropic glutamate receptor 7 precursor; Hs-mGluR8 gi 12644040 sp O00222 MGR8_HUMAN Metabotropic glutamate receptor 8 precursor; Hs-mGABABR1 gi 10835015 ref NP_001461.1 gamma-aminobutyric acid (GABA) B receptor 1 isoform α precursor; [Homo sapiens]; Hs-mGABABR2 gi 5639667 gb AAD45867.1 AF099033_1 gamma-aminobutyric acid type B receptor 2 [Homo sapiens]; Mm-CASR, PA1138 spid=Q9QY96 EXTRACELLULAR CALCIUM-SENSING RECEPTOR PRECURSOR (CASR) (PARATHYROID CELL CALCIUM-SENSING RECEPTOR); Mm-V2R1, PB7496 gp=NP_064301 tissue-type vomeronasal neurons putative pheromone receptor V2R1; Mm-V2R2,gi 2996016 gb AAC08413.1 putative pheromone receptor V2R2 [Mus]; Mm-V2R2-like, PC22454 ri=4930518C23 weakly similar to; Mm-V2R2-like, PC22632 ri=4933425M15 similar to PUTATIVE PHEROMONE RECEPTOR V2R2; Mm-VR, gi 2367454 gb AAC53402.1 putative pheromone receptor [Mus musculus]; Dm-gi 17380359 sp P91685 MGR_DROME Metabotropic glutamate receptor precursor; Dm-gi 21627691 gb AAF59082.2 CG30361-PB [Drosophila melanogaster]; Dm-gi 10727404 gb AAF51465.2 CG3022-PA [Drosophila melanogaster]; Dm-gi 7291590 gb AAF47013.1 CG18678-PA [Drosophila melanogaster]; Dm-gi 22946517 gb AAF53431.2 CG15274-PA [Drosophila melanogaster]; Dm-gi 7300772 gb AAF55916.1 CG6706-PB [Drosophila melanogaster]; Dm-gi 22945210 gb AAF50967.2 CG31660-PB [Drosophila melanogaster]; Dm-gi 23094276 gb AAF51767.2 CG32447-PA [Drosophila melanogaster]; Dm-gi 22946313 gb AAF53175.2 CG31860-PA [Drosophila melanogaster]; Dm-gi 1834421 emb CAA39373.1 bride of sevenless protein [Drosophila melanogaster]; Dm-gi 2495081 sp Q09630 MGR1_CAEEL PROBABLE METABOTROPIC GLUTAMATE RECEPTOR MGL-1; Ce-gi 3877264 emb CAB01711.1 Similarity to Rat metabotropic glutamate receptor (SW:MGR1_RAT), contains similarity to Pfam domain: PF00003 (7 transmembrane receptor [metabotropic glutamate family]), [Caenorhabditis elegans]; Ce-gi 15145337 gb AAA81683.2 Hypothetical protein F35H10.10 [Caenorhabditis elegans]; Ce-gi 1326348 gb AAB52965.1 Hypothetical protein ZK180.1 [Caenorhabditis elegans]; Ce-gi 16950478 gb AAL32243.1 AC006761_4 Hypothetical protein Y41G9A.4a [Caenorhabditis elegans]; Ce-gi 20338952 emb CAB07388.2 [Caenorhabditis elegans]; PA2376 spid=P23242 GAP JUNCTION ALPHA-1 PROTEIN (CONNEXIN 43) (CX43).
