Comparative Analysis of Apoptosis and Inflammation Genes of Mice and Humans

Table 2.

Comparison of Caspases of Mice and Humans


Protein

Human

Mouse

NCBI gi

RIKEN
Caspase-1 + + 266322 N/A
Caspase-2 + + 2506262 A630056A17
Caspase-3 + + 6753284 3110059017
A830040C14
Caspase-4 + - Not present Not present
Caspase-5 + - Not present Not present
Caspase-6 + + 6753286 2610037G10
Caspase-7 + + 6680850 C130071H08
Caspase-8 + + 20847456 N/A
Caspase-9 + + 7656963 D430036C13
Caspase-10 + - Not present Not present
Caspase-11 - + 6671682 903008106
Caspase-12 - + 6753278 5031429D02
Caspase-14 + + 6753280 C130060A16
Para-Caspase
+
+
Not present
D430033E09
  • The Caspases of humans and mice are compared. The murnine cDNAs found exclusively in the RIKEN database are indicated. (N/A) Not applicable, indicating the gene was already present at NCBI or that mice lack this gene. Note that Caspase-13 was subsequently recognized to represent a bovine cDNA that contaminated a human library. The human ortholog of murine Caspase-12 is non-functional (Fischer et al. 2002). Representative genes are indicated by NCBI gi number corresponding to the protein record or RIKEN cDNA clone identification numbers. Minus sign indicates that a murine ortholog was not found

This Article

  1. Genome Res. 13: 1376-1388

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