Membrane Organization of Protein Classes Assigned Based on the Prediction of Signal Peptides and Transmembrane Domains
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|
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S. cerevisciae |
A. thaliana |
D. melanogaster |
C. elegans |
Riken RPS |
Riken VPS |
M. musculus (IPI) |
Mouse genome (Ensembl) |
H. sapiens (IPI) |
Human genome (Ensembl) |
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| Class |
Description |
Number |
% |
Number |
% |
Number |
% |
Number |
% |
Number |
% |
Number |
% |
Number |
% |
Number |
% |
Number |
% |
Number |
% |
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| A | Soluble nonsecreted proteins | 4107 | 68.6 | 16,467 | 63.6 | 8474 | 61.4 | 10,672 | 53.7 | 10,161 | 59.0 | 19,267 | 59.4 | 11,288 | 57.4 | 9117 | 57.6 | 15,057 | 61.0 | 10,336 | 60.4 | ||||||||||
| B | Soluble secreted proteins | 252 | 4.2 | 2354 | 9.1 | 1815 | 13.2 | 2469 | 12.4 | 2040 | 11.9 | 3862 | 11.9 | 2378 | 12.1 | 1908 | 12.1 | 2776 | 11.2 | 2119 | 12.4 | ||||||||||
| C | Type I membrane proteins (single span, secreted) | 117 | 2.0 | 777 | 3.0 | 335 | 2.4 | 636 | 3.2 | 935 | 5.4 | 1843 | 5.7 | 977 | 5.0 | 751 | 4.7 | 1361 | 5.5 | 864 | 5.1 | ||||||||||
| D | Type II membrane proteins (single span, nonsecreted) | 300 | 5.0 | 1542 | 6.0 | 651 | 4.7 | 1072 | 5.4 | 804 | 4.7 | 1497 | 4.6 | 779 | 4.0 | 598 | 3.8 | 953 | 3.9 | 655 | 3.8 | ||||||||||
| E | Multimembrane spanning proteins | 820 | 13.7 | 2810 | 10.8 | 1676 | 12.2 | 3816 | 19.2 | 2096 | 12.2 | 3839 | 11.8 | 3017 | 15.3 | 2478 | 15.7 | 2843 | 11.5 | 2030 | 11.9 | ||||||||||
| F | Membrane organization not annotated | 388 | 6.5 | 1951 | 7.5 | 840 | 6.1 | 1221 | 6.1 | 1173 | 6.8 | 2129 | 6.6 | 1216 | 6.2 | 980 | 6.2 | 1711 | 6.9 | 1099 | 6.4 | ||||||||||
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Total full-length ORFs
|
|
5984
|
25,901
|
13,791
|
19,886
|
17,209
|
32,437
|
19,655
|
15,832
|
24,701
|
17,103
|
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Protein classes are determined by the following annotations: Class A, signal peptide (SP)-negative, transmembrane domain (TD)-negative; Class B, SP-positive, TD-negative; Class C, SP-positive, single TD-positive; Class D, SP-negative, single TD-positive; Class E, SP-positive or negative, transmembrane domains multiple positives per protein; Class F, no consensus in SP and/or TD predictions. Percentages are given as a percentage of the total full-length ORFs. Results used to compile Table 4 are available from http://microarray.imb.uq.edu.au/predictors/proteome/
