Kinase Pathway Database: An Integrated Protein-Kinase and NLP-Based Protein-Interaction Resource

Table 5.

Summary of the Template Phrase Pattern Types


Pattern type/pattern example

Example of sentence
Predicate verb
NP1 activate NP2 It has recently been reported that <rifampicin> activates the <glucocorticoid receptor>.
NP1 bind NP2 We were able to confirm that <Tap> can indeed bind <p 15 specifically both in_vivo and in_vitro>.
NP1 induce NP2 These results demonstrate that <TNF-alpha and IFN-gamma> induce <expression of functional FasL in adenocarcinoma cels>.
NP1 regulate NP2 <Transfection-mediated expression of wild-type p53> has been shown to negatively regulate <basal promoter activity of MGMT in_vitro>.
NP interact Further analysis confirmed that <Vav and Ly-GDI> interact both in_vitro and in_vivo assays.
etc.
Predicate verb-preposition
NP1 interact with NP2 <Gadd45> was also able to physically interact with <Cdc2>.
NP1 bind to NP2 Here we report that <PKR> binds to <p53>.
etc.
Predicate verb-phrase
NP1 form <[a-z]* complex with NP2> We demonstrate that <Pap> forms <a stable complex with Pyk2>.
NP1 involve in <regulation of NP2> Recent animal studies indicate that <leptin> is involved in the <regulation of blood pressure through the leptin receptor>.
NP1 be <[a-z]* substrate of NP2> <HIP-55> were <direct substrates of caspase 3>.
NP1 play <[a-z]* role in NP2> <Hsp90> plays an <important role in the rapid, estrogen receptor-mediated modulation of eNOS>.
NP1 regulate <[a-z]* through degradation of NP2> Here we report that <Ubr1p, the main recognition component of this pathway>, regulates <peptide import in the yeast Saccharomyces cerevisiae through degradation of Cup9p, a 35 kDa homeodomain protein>.
NP1 serve as <inhibitor of NP2> CHOP serves as an <inhibitor of the activity of C/EBP proteins>.
etc.
Noun-phase
Induction of NP1 by NP2 It was concluded that the <induction of MCP-3 by IFN> is regulated differently in fibroblasts and PBMC.
Activation of NP1 by either NP2 or NP2' <Activation of p38 by either opsonized zymosan or lgG-coated SRBC> was similar in wild-type and rac2 (-/-) cells.
Effect of NP1 on NP2 The <effect of c-myc on down-regulation of Fas expression> was found.
Interaction between NP1 and NP2 The <interaction between ILK and PINCH> has been consistently observed under a variety of experimental conditions.
Phosphorylation of NP1 through NP2 These data suggest that SLF enhances <integrin-fibronectin-dependent tyrosine phosphorylation of pp 125FAK through activation of integrin>.
NP1 mediated NP2 Here we demonstrate that an enhancer element can suppress the <P-Ph-mediated inhibition of yellow transcription>.
Binding of NP1 to NP2 Phosphorylation of MAPK of the critical serine residue (Ser 127) of the Drosophila transcription factor Yan depends on Mae, and is mediated by the <binding of Yan to Mae through their Pointed domain>.
etc.

  • NP1 and NP2 are noun-phrase including protein/gene/compound names.

    < > shows the extended noun-phrase concerning information extraction.

    Bold letters indicate protein/gene/compound names, and the underlined parts indicate template phrase patterns.

    The articles and demonstrative pronouns are ignored in the pattern matching.

This Article

  1. Genome Res. 13: 1231-1243

Preprint Server