eVOC Extends the Expression Information That Can be Obtained From Other Sources
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Isoform 1 |
Isoform 2 |
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Gene name
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Xu et al.
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eVOC
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Xu et al.
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eVOC
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| IRP3 | Brain-specific | 5 nervous → brain | No specificity | 2 urogenital → genital → female → uterus | ||
| 1 respiratory → lung | 1 urogenital → genital → female → placenta | |||||
| 1 haematological → blood | ||||||
| 4 infant | 3 adult | |||||
| WNK1 | Kidney-specific | 7 urinary → kidney | No specificity | 2 urogenital → genital male → penis | ||
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1 alimentary → pancreas
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IRP3, described by Xu et al. (2002) as having a brain-specific isoform, was shown to be infant brain specific by combining information gathered from the eVOC ontologies. The ESTs for each isoform were submitted to eVOC and the associated terms in each of the four ontologies were examined to identify expression state specificity. Five of the six ESTs from distinct cDNA libraries were found to support the brain specificity reported by Xu et al. (2002). Further, using eVOC, four of the six libraries had been annotated with developmental stage information, and this was used to confirm that isoform 1 of IRP3 is only observed in infant libraries.
