Multimeric Threading-Based Prediction of Protein–Protein Interactions on a Genomic Scale: Application to the Saccharomyces cerevisiae Proteome

Table 1.

Comparison of Distributions of Predicted Interactions in Functional Categories for Large-Scale Studies
MTAa
TAPb
HMSc
Y2Hd
RNAe
SILf
SYNg
TAP 0.170
HMS 0.461 0.346
Y2H 0.436 0.518 0.325
RNA 0.701 0.087 0.384 0.060
SIL 0.556 0.350 0.474 0.023 0.740
SYN 0.578 0.332 0.107 0.677 0.016 0.005
HCh
0.739
0.488
0.542
0.318
0.869
0.799
0.248

  • ↵a Our Multimeric Threading Algorithm.

  • ↵b TAP complexes.

  • ↵c HMS-PCI complexes.

  • ↵d Yeast two-hybrid.

  • ↵e Correlated mRNA expression.

  • ↵f Other in silico methods.

  • ↵g Synthetic lethality.

  • ↵h High confidence interactions, i.e., the interactions determined by at least two different large-scale methods.

This Article

  1. Genome Res. 13: 1146-1154

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