Table 1.
Expression of Midkine Genes in Vertebrates
|
Species |
Embryonic expression |
Adult expression |
References |
|---|---|---|---|
| Human | liver, kidney; others nd. | not expressed, except in kidney and at very low levels in brain; highly expressed in certain tumors | Mishima et al. 1997 Kato et al. 2000 |
| Mouse | ubiquitous from E5.5 to E11 in brain, neural tube, upper and lower jaw, lung, scelerotome, limbs, intestine, stomach, pancreas, kidney from E11.5 to E13.5 | not expressed, except in kidney and at very low levels in brain | Kadomatsu et al. 1988 Kadomatsu et al. 1990 Muramatsu et al. 1993 Mitsiadis et al. 1995 Fan et al. 2000 |
| restricted to kidney at E15 | |||
| Xenopus | brain, branchial arches, neural tube | strong in brain, kidney, spleen, eye, spinal cord; weak in heart, lung, testis, stomach; not expressed in liver, intestine, muscle | Sekiguchi et al. 1995 |
| Chicken | throughout embryo but excluded from neural tube | nd. | Duprez et al. 1993 |
| Zebrafish mdka | paraxial mesoderm and somites; central neural tube; restricted areas in brain; | strong in brain; others nd. | this report |
|
Zebrafish mdkb
|
restricted areas in the dorsal CNS
|
strong in brain; others nd.
|
Winkler and Moon 2001; this report
|
-
(nd) Not determined.
