Predicting Gene Ontology Biological Process From Temporal Gene Expression Patterns

Table 5.

Classifications Obtained With the Model

Process Annotate genes Reclassifications for known genes (correct) Classifications for unknown genes
Ion homeostasis 4 4 (4) 4
Protein targeting 6 8 (6) 2
Blood coagulation 10 13 (10) 34
DNA metabolism 19 33 (19) 28
Intracellular signaling cascade 26 39 (25) 14
Energy pathways 6 6 (6) 0
Cell cycle 47 66 (44) 38
Oncogenesis 17 41 (17) 31
Circulation 15 17 (15) 3
Cell death 16 22 (16) 26
Developmental processes 15 23 (15) 21
Transcription 52 61 (47) 88
Defense (immune) response 37 44 (32) 20
Cell adhesion 30 32 (29) 19
Stress response 17 26 (17) 22
Protein metabolism and modification 33 45 (33) 35
Cell motility 32 40 (29) 21
Cell surface receptor linked signal transduction 27 38 (26) 34
Lipid metabolism 26 44 (25) 45
Transport 22 30 (22) 19
Cell organization and biogenesis 33 40 (30) 13
Cell proliferation 53 60 (46) 30
Amino acid and derivative metabolism 6 6 (6) 2
  • Summary of reclassification of known genes and classification of unknown genes to the 23 broad biological function classes by using the model evaluated in Table 4.

This Article

  1. Genome Res. 13: 965-979

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