Predicting Gene Function From Patterns of Annotation

Table 1.

Top 50 Hypotheses for FlyBase Using Model M DT, Sorted Alphabetically by GO Attribute

Rating Gene name GO attribute
1 Pros28.2 C-20S core proteasome
1 CG1268 C-hydrogen-transporting ATPase V0  domain
2 CG1268 C-hydrogen-transporting ATPase V1  domain
3 CG5235 C-microsome
3 CG7495 C-microsome
3 Cyp12a2 C-microsome
3 Cyp450_U5csm C-microsome
3 Tbh C-microsome
1 CG1909 C-nicotinic acetylcholine-gated  receptor-channel
3 Thor F-antibacterial peptide
1 Dhc1 F-dynein ATPase
3 syd F-dynein ATPase
3 Unc-76 F-dynein ATPase
1 bip2 F-general RNA polymerase II  transcription factor
2 Hsf F-heat shock protein
3 Ubi-p63E F-heat shock protein
1 cnn F-myosin ATPase
3 CG4536 F-olfactory receptor
3 lush F-olfactory receptor
3 TyrR F-olfactory receptor
1 CG6905 F-pre-mRNA splicing factor
3 REG F-proteasome endopeptidase
3 Tl F-scavenger receptor
3 CG4980 F-small nuclear ribonucleoprotein  (now obsolete)
3 CG6905 F-small nuclear ribonucleoprotein  (now obsolete)
2 CG4980 F-small nuclear RNA (now obsolete)
2 CG6905 F-small nuclear RNA (now obsolete)
1 bnk F-structural protein of cytoskeleton
1 Cortactin F-structural protein of cytoskeleton
1 CG12740 F-structural protein of ribosome
1 CG12775 F-structural protein of ribosome
3 PK11 F-taste receptor
3 PK19 F-taste receptor
3 Voila F-taste receptor
2 CG4415 F-transfer RNA (now obsolete)
1 trp&ggr P-calcium ion transport
1 Ulp1 P-deubiquitylation
1 Cdic P-microtubule-based movement
3 CG10845 P-microtubule-based movement
3 CG1193 P-microtubule-based movement
1 kl-2 P-microtubule-based movement
3 shi P-microtubule-based movement
3 unc-104 P-microtubule-based movement
1 CG14060 P-mRNA splicing
1 CG4980 P-mRNA splicing
1 CG5931 P-mRNA splicing
1 CG7972 P-mRNA splicing
1 AGO1 P-protein synthesis initiation
1 CG12413 P-protein synthesis initiation
1 1(2)01424 P-protein synthesis initiation
  • The first column gives the curator's rating of each hypothesis, with 1 meaning “known to be true,” 2 meaning “known to be false,” and 3 meaning “neither of the above.”

This Article

  1. Genome Res. 13: 896-904

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