Discovering Novel cis-Regulatory Motifs Using Functional Networks

Table 2.

Known Transcription Factor Binding Sites That Have a Significant Overlap Score

Transcription factors References Observed genes Consensus KEGG Cellzome MDS
MET 31/32 (Blaiseau et al. 1997) Methionine biosynthesis AAACTGTG 5.25 1.46 0.96
HAP2 (Mantovani 1998) Oxidative phosphorylation ACCAAT.A 6.51 0.11 1.36
GRF2/REB1 (Chasman et al. 1990) Unknown [TC]..[TC][TC]ACCCG 1.88 4.62 3.45
[TC]..[TC][TC]ACCCT 1.27 2.82 4.38
PHO4 (Hayashi and Oshima 1991) Met, Thr, Asn synthesis CACGTG 6.36 1.95 1.94
MBP1/MBF1 (Lowndes et al. 1991) DNA replication ACGCGT.A 4.41 4.74 3.81
RPN4p (Mannhaupt et al. 1999) Proteasome GGTGGCAAA 0.33 11.62 13.46
GCN4 (Hope and Struhl 1985) Amino acids synthesis TGACTCA 8.66 3.39 2.87
CBF1 (Dowell et al. 1992) Unknown TCAC.TGA 5.21 0.5 1.23
TFIID-TBP (Struhl 1995) Unknown TATATAAA 4.91 1.39 3.61
  • The values are the standard deviations from the mean of random overlap score. Values in bold are significant. The “Observed gene” column is a functional annotation based on the overlap gene annotations.

This Article

  1. Genome Res. 13: 883-895

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