Neutral Substitutions Occur at a Faster Rate in Exons Than in Noncoding DNA in Primate Genomes

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Figure 2.
Figure 2.

Relationship between evolutionary divergence and the ratio of CpG contents in pseudogenes and their functional counterparts. (A) Analysis of 39 human pseudogenes [R 2 = 0.52;P < 0.01], (B) seven pseudogenes created from the same Arginino succinate synthetase gene [R 2 = 0.90; P < 0.01], and (C) five pseudogenes of the same Beta tubulin Q gene [R 2 = 0.73; P < 0.05]. The relative CpG content is the ratio of the overall CpG content in the pseudogene divided by overall CpG content of the functional gene.

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  1. Genome Res. 13: 838-844

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